positive allosteric modulator(BMS986187)-bound delta-opioid receptor-Gi complex

2026-03-11 REL PDBc INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY DATABASE_REFERENCES citation citation_author em_admin _citation.country _citation.journal_abbrev _citation.journal_id_CSD _citation.journal_id_ISSN _citation.journal_volume _citation.page_first _citation.page_last _citation.pdbx_database_id_DOI _citation.pdbx_database_id_PubMed _citation.title _citation.year _em_admin.last_update EXPERIMENTAL_SUMMARY citation citation_author em_admin _citation.country _citation.journal_abbrev _citation.journal_id_CSD _citation.journal_id_ISSN _citation.journal_volume _citation.page_first _citation.page_last _citation.pdbx_database_id_DOI _citation.pdbx_database_id_PubMed _citation.title _citation.year _em_admin.last_update PDBj PDBc 2024-02-03 2026-01-07 2026-01-07 2026-03-11 National Natural Science Foundation of China (NSFC) 32130022 China National Natural Science Foundation of China (NSFC) 82121005 China positive allosteric modulator(BMS986187)-bound delta-opioid receptor-Gi complex Luo P Xu Y Wang Y Zhuang Y Xu HE positive allosteric modulator, BMS986187, delta-opioid receptor, allosteric agonism, allosteric opioid analgesics, MEMBRANE PROTEIN Wang Y Luo P Xu H Zhan L Sakamoto K Li M Wang J Huang XP Zhou J Liu T Suo Y Fan W He X Xu Y Cai Y Wang C Zhao Y Dai A Lai Y Yuan Q Hu W Wu K Yang D Cheng X Lu X Krumm B Kenakin T Zhang J Roth BL Gao Z Xu HE Zhuang Y Structure-based design of an opioid receptor modulator for enhanced morphine analgesia. Sci Adv US 12 eaea9832 eaea9832 2026 41671375 doi:10.1126/sciadv.aea9832 2375-2548 8y71 FULLOVERLAP EMDB EMD-39009 associated EM volume

positive allosteric modulator(BMS986187)-bound delta-opioid receptor-G complex positive allosteric modulator(BMS986187)-bound delta-opioid receptor-G complex 0 1 2 3 4 5 Homo sapiens Guanine nucleotide-binding protein G(i) subunit alpha-1 Homo sapiens 0.040445059 1 Spodoptera frugiperda LEVO MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQS IIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLD RIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGAQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIY THFTCSTDTKNVQFVFDAVTDVIIKNNLKDCGLF P63096 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Rattus norvegicus 0.040226991999999996 1 Spodoptera frugiperda LEVO MGSLLQSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQ DGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFF PNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRV SCLGVTDDGMAVATGSWDSFLKIWNGSSGGGGSGGGGSSGVSGWRLFKKIS P54311 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Bos taurus 0.007563749999999999 1 Spodoptera frugiperda LEVO MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFC P63212 scFv16 synthetic construct 0.026408492 1 Spodoptera frugiperda LEVO MVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAPEKGLEWVAYISSGSGTIYYADTVKGRFTISRDDPKNTLF LQMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTLTVSAGGGGSGGGGSGGGGSADIVMTQATSSVPVTPGESVSISC RSSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLEAEDVGVYYCMQHLEYPLTF GAGTKLEL Delta-type opioid receptor Homo sapiens 0.05748498 1 Spodoptera frugiperda LEVO EPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMK TATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT PAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLR SVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFL DENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPVFTLEDFVGDWEQTAAYNLDQVLEQGGVSSLLQNL AVSVTPIQRIVRSGENALKIDIHVIIPYEGLSADQMAQIEEVFKVVYPVDDHHFKVILPYGTLVIDGVTPNMLNYFGRPY EGIAVFDGKKITVTGTLWNGNKIIDERLITPDGSMLFRVTINS P41143 3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-4,5,7,9-tetrahydro-2~{H}-xanthene-1,8-dione 0.000470599 1 A1D6B 4-[(~{S})-[(2~{R},5~{S})-2,5-dimethyl-4-prop-2-enyl-piperazin-1-yl]-(3-methoxyphenyl)methyl]-~{N},~{N}-diethyl-benzamide 0.000449628 1 A1D6F singleParticle particle 7.2 ETHANE TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 1.0 2.0 GATAN K3 (6k x 4k) 50.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 2.97 FSC 0.143 CUT-OFF RELION 280347 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_39009.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 247.2 247.2 247.2 90.0 90.0 90.0 X Y Z -0.013806239 0.030951327 0.00006262745 0.0006615098 0.824 0.824 0.824 0.0055 AUTHOR ::::EMDATABANK.org::::EMD-39009:::: emd_39009_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 247.2 247.2 247.2 90.0 90.0 90.0 X Y Z -0.011281418 0.028238367 -0.00001852588 0.0007799444 0.824 0.824 0.824 AUTHOR ::::EMDATABANK.org::::EMD-39009:::: emd_39009_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 247.2 247.2 247.2 90.0 90.0 90.0 X Y Z -0.012189524 0.027094912 -0.000018298611 0.0007789353 0.824 0.824 0.824 AUTHOR ::::EMDATABANK.org::::EMD-39009::::