STING oligomer bound to cGAMP and STG2 in the presence of PI4P

2026-02-18 REL RCSB INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY DATABASE_REFERENCES citation citation_author em_admin _citation.country _citation.journal_abbrev _citation.journal_id_ASTM _citation.journal_id_CSD _citation.journal_id_ISSN _citation.pdbx_database_id_DOI _citation.title _citation.year _em_admin.last_update EXPERIMENTAL_SUMMARY citation citation_author em_admin _citation.country _citation.journal_abbrev _citation.journal_id_ASTM _citation.journal_id_CSD _citation.journal_id_ISSN _citation.pdbx_database_id_DOI _citation.title _citation.year _em_admin.last_update DATABASE_REFERENCES citation citation_author em_admin _citation.pdbx_database_id_PubMed _citation.title _citation_author.identifier_ORCID _citation_author.name _em_admin.last_update EXPERIMENTAL_SUMMARY citation citation_author em_admin _citation.pdbx_database_id_PubMed _citation.title _citation_author.identifier_ORCID _citation_author.name _em_admin.last_update RCSB RCSB 2024-08-22 2025-12-17 2025-12-17 2026-02-18 National Institutes of Health/National Cancer Institute (NIH/NCI) R01CA273595 United States Welch Foundation I-1702 United States Welch Foundation I-1944 United States STING oligomer bound to cGAMP and STG2 in the presence of PI4P Li J Zhang X Bai X STING, lipid, oligomerization, SIGNALING PROTEIN, SIGNALING PROTEIN-ACTIVATOR complex Li J Tan JX Chen ZJ Zhang X Bai XC Regulation of STING activation by phosphoinositide and cholesterol. Nature UK 2026 41639452 doi:10.1038/s41586-025-10076-0 1476-4687 0006 NATUAS 9dav FULLOVERLAP PDB 9DAN unspecified PDB 9DAT unspecified EMDB EMD-46699 associated EM volume

STING oligomer bound to its ligand cGAMP, a synthetic activator named STG2, in the presence of Cholesteryl hemisuccinate and PI4P STING oligomer bound to its ligand cGAMP, a synthetic activator named STG2, in the presence of Cholesteryl hemisuccinate and PI4P 0 1 Homo sapiens Stimulator of interferon genes protein Homo sapiens 0.039553398 4 Homo sapiens LEVO MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGS YWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLA WSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVY SNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADD SSFSLSQEVLRHLRQEEKEEVTVGTSSGLEVLFQ Q86WV6 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid 0.000427533 2 Y6H cGAMP 0.0006744109999999999 2 1SY singleParticle particle 7.4 ETHANE FEI TITAN KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 1.0 2.5 GATAN K3 BIOQUANTUM (6k x 4k) 1.2 1 PHASE FLIPPING AND AMPLITUDE CORRECTION EMD-29282 2.8 FSC 0.143 CUT-OFF 450101 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_46699.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 328 328 328 0 0 0 328 328 328 258.464 258.464 258.464 90.0 90.0 90.0 X Y Z -0.029389013 0.05024168 0.00006092536 0.001253654 0.788 0.788 0.788 0.007 AUTHOR ::::EMDATABANK.org::::EMD-46699:::: emd_46699_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 328 328 328 0 0 0 328 328 328 258.464 258.464 258.464 90.0 90.0 90.0 X Y Z -0.019851878 0.031899486 0.00003148465 0.0021016784 0.788 0.788 0.788 AUTHOR ::::EMDATABANK.org::::EMD-46699:::: emd_46699_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 328 328 328 0 0 0 328 328 328 258.464 258.464 258.464 90.0 90.0 90.0 X Y Z -0.020019466 0.030734241 0.00003125749 0.0021020218 0.788 0.788 0.788 AUTHOR ::::EMDATABANK.org::::EMD-46699::::