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        <sites>
            <deposition>RCSB</deposition>
            <last_processing>RCSB</last_processing>
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        <key_dates>
            <deposition>2024-11-15</deposition>
            <header_release>2025-07-30</header_release>
            <map_release>2025-07-30</map_release>
            <update>2025-10-01</update>
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        <grant_support>
            <grant_reference>
                <funding_body>National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS)</funding_body>
                <code>1R01NS140149-01</code>
                <country>United States</country>
            </grant_reference>
        </grant_support>
        <title>Human LARP1 bound to the 40S small ribosomal subunit</title>
        <authors_list>
            <author>Dong W</author>
            <author>Kaufhold R</author>
            <author>Brito Querido J</author>
        </authors_list>
        <keywords>LARP1, ribosome, translation, mRNA, TOP</keywords>
    </admin>
    <crossreferences>
        <citation_list>
            <primary_citation>
                <journal_citation published="true">
                    <author order="1">Wolin E</author>
                    <author order="2">Guo JK</author>
                    <author order="3">Blanco MR</author>
                    <author order="4">Goronzy IN</author>
                    <author order="5">Gorhe D</author>
                    <author order="6">Dong W</author>
                    <author order="7">Perez AA</author>
                    <author order="8">Keskin A</author>
                    <author order="9">Valenzuela E</author>
                    <author order="10">Abdou AA</author>
                    <author order="11">Urbinati CR</author>
                    <author order="12">Kaufhold R</author>
                    <author order="13">Rube HT</author>
                    <author order="14">Brito Querido J</author>
                    <author order="15">Guttman M</author>
                    <author order="16">Jovanovic M</author>
                    <title>SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress.</title>
                    <journal_abbreviation>Cell</journal_abbreviation>
                    <volume>188</volume>
                    <first_page>5384</first_page>
                    <last_page>5402.e25</last_page>
                    <year>2025</year>
                    <external_references type="PUBMED">40701149</external_references>
                    <external_references type="DOI">doi:10.1016/j.cell.2025.06.042</external_references>
                    <external_references type="ISSN">1097-4172</external_references>
                </journal_citation>
            </primary_citation>
        </citation_list>
        <pdb_list>
            <pdb_reference>
                <pdb_id>9ed0</pdb_id>
                <relationship>
                    <in_frame>FULLOVERLAP</in_frame>
                </relationship>
            </pdb_reference>
        </pdb_list>
        <other_db_list>
            <db_reference>
                <db_name>EMDB</db_name>
                <accession_id>EMD-47929</accession_id>
                <content_type>associated EM volume</content_type>
                <details>Human LARP1 bound to the 40S small ribosomal subunit</details>
            </db_reference>
        </other_db_list>
    </crossreferences>
    <sample>
        <name>40S-LARP1</name>
        <supramolecule_list>
            <complex_supramolecule supramolecule_id="1">
                <name>40S-LARP1</name>
                <parent>0</parent>
                <macromolecule_list>
                    <macromolecule>
                        <macromolecule_id>2</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>3</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>4</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>5</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>7</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>8</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>9</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>10</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>11</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>12</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>14</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>15</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>16</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>17</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>18</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>19</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>20</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>21</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>22</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>23</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>24</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>25</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>26</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>27</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>29</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>30</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>32</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>34</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>35</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>36</macromolecule_id>
                    </macromolecule>
                </macromolecule_list>
                <details>Human LARP1 bound to the 40S small ribosomal subunit</details>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
            </complex_supramolecule>
        </supramolecule_list>
        <macromolecule_list>
            <rna macromolecule_id="1">
                <name>rRNA</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.603490062</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <sequence>
                    <string>UACCUGGUUGAUCCUGCCAGUAGCAU(A2M)UGCUUGUC(PSU)CAAAGAUUAAGCCAUGCAUGUCUAAGUACGCACGGC
CGGUACAGUGAAACUGCGAA(PSU)GGCUC(A2M)UUAAA(PSU)CAG(PSU)UAUGGU(OMU)CC(PSU)U(OMU)GGU
CGCUCGCUCCUCUCCCACUUGGAUAACUGUGGUA(A2M)UUCUAG(A2M)GCUAA(OMU)A(OMC)AUGCCGACGGGCGC
UGACCCCCUUCGCGGGGGGGAUGCGUGCAUUUAUCAGAUCAAAACCAACCCGGUCAGCCCCUCUCCGGCCCCGGCCGGGG
GGCGGGCCGCGGCGGCUUUUGGUGACUC(PSU)AGAUAACCUCGGGCCGAUCGCACGCCCCCCGUGGCGGCGACGACCCA
UUCGAACGUC(OMU)GCCCUAUCAACUUUCGAUGGUAGUCGCCGUGCCUACCAUGGUGACCACGGG(PSU)GACGGGGAA
UCAGGGUUCGAU(OMU)CCGGAGA(OMG)GGAGCCUGAGAAACGGCUACCACAU(OMC)CAAGG(A2M)AGGCAGCAGGC
GCGC(A2M)AAUUACCCACUCCCGACCCGGGGA(OMG)GU(A2M)GUGA(OMC)GAAAAAUAACAAUACAGGACUCUUUC
GAGGCCCUGUAAUUGGAAUGAGUCCACU(PSU)UAA(A2M)UCCUUCCACGAGG(A2M)UCCAUUGGAG(OMG)GCAAGU
CUGGUGCCAGCAGCCGCGGUAAUUCCAGCUCCAAUA(OMG)CGUA(PSU)A(PSU)UAAAGUUGCUGCAGUU(A2M)AAA
AGCUCGUAG(PSU)U(OMG)GA(PSU)CUUGGGAGCGGGCGGGCGGUCCGCCGCGAGGCGAGCCACCGCCCGUCCCCGCC
CCUUGCCUCUCGGCGCCCCCUCGAUGCUCUUAGCUGAGUGUCCCGCGGGGCCCGAAGCGUUUACUUUGAAAAAA(PSU)
(PSU)AGAGUG(PSU)UCAAAGCAGGCCCGAGCCGCCUGGAUACCGCAGCUAGGAA(PSU)AAUGGAAUAGGACCGCGGU
UCUAUUUUGUUGGUUUUCGGAACUGAGGCCAUGAUUAAGAGGGACGGCCGGGGGCAUUCGUAUUGCGCCGCUAGAGGUGA
AAUUCUUGGACCGGCGCAAGACGGACCAGAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGA(A2M)CGAAAGU
CGGAGG(PSU)(PSU)CGAAGACGA(PSU)CAGAUACCGUCGUAGUUCCGACCA(PSU)AAACGAUGCCGACUGGCGAUG
CGGCGGCGUUAUUCCCAUGACCCGCCGGGCAGC(PSU)UCCGGGAAACCAAAGUCUUUGGGUUCCGGGGGGAGUA(PSU)
GG(PSU)UGCAAAGCUGAAACUUAAAGGAAUUGACGGAAGGGCACCACCAGGAGUGGAGCC(PSU)GCGGC(PSU)UAAU
U(PSU)GAC(B8N)CAACACGGGAAACCUCACCCGGC(OMC)CGGACACGGACAGGA(OMU)UGACAGAUUGAUAGCUCU
UUCUCGAUUCCGUGGGUGG(OMU)G(OMG)UGCAUGGC(4AC)GUUCUUAGU(PSU)GGUGGAGCGAUUUGUCUGGUUAA
UUCCGAUAACGA(A2M)CGAGACU(OMC)UGGCAUGCUAACUAGUUACGCGACCCCCGAGCGGUCGGCGUCCCCCAACU
(OMU)CU(PSU)A(OMG)AGGGACAAGUGGCGUUCAGCCACCCGAGAUUGAGCAAUAACA(OMG)GUCUGUGAUGCCCUU
AGAUGUCCGGGGCUGCACGCGCGCUACACUGACUGGCUCAGCGUGUGCCUACCCUACGCCGGCAGGCGCGGGUAACCCGU
UGAACCCCAUUCGUGAUGGGGAUCGGGGAUUGCAAUUAU(PSU)CCCCAUGAACGAG(7MG)AAU(PSU)CCCAGUAAGU
GCGGGUCAUAAGCUUGCGUUGAUU(A2M)AGUCCCUGCCCUU(PSU)GUACACACCG(OMC)CCGUCGCUACUACCGAUU
GGAUGGUUUAGUGAGGCCCUCGGAUCGGCCCCGCCGGGGUCGGCCCACGCCCUGGCGGAGCGCUGAGAAGACGGUCGAAC
UUGACUAUCUAGAGGAAGUAAAAGUCGUA(6MZ)CAAGGUUUC(4AC)GUAGGUG(MA6)(MA6)CCUGCGGAAGGAUCA
UUA</string>
                </sequence>
            </rna>
            <protein_or_peptide macromolecule_id="2">
                <name>Small ribosomal subunit protein uS2</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.032883938</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSR
NTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIA
IPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTA
TQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS</string>
                    <external_references type="UNIPROTKB">P08865</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="3">
                <name>Small ribosomal subunit protein eS1</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.030002061</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVA
FRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQ
VRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGSSSGK
ATGDETGAKVERADGYEPPVQESV</string>
                    <external_references type="UNIPROTKB">P61247</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="4">
                <name>Small ribosomal subunit protein uS5</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.031376516</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MADDAGAAGGPGGPGGPGMGNRGGFRGGFGSGIRGRGRGRGRGRGRGRGARGGKAEDKEWMPVTKLGRLVKDMKIKSLEE
IYLFSLPIKESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKL
SIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKAT
FDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLVKTHTRVSVQRTQAPAVATT</string>
                    <external_references type="UNIPROTKB">P15880</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="5">
                <name>Small ribosomal subunit protein uS3</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.026729368999999996</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFP
EGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHS
GDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQKGGKPEPPAMPQPV
PTA</string>
                    <external_references type="UNIPROTKB">P23396</external_references>
                </sequence>
                <ec_number>4.2.99.18</ec_number>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="6">
                <name>Small ribosomal subunit protein eS4, X isoform</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.029654868999999997</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDI
TYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTI
QIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPR
GKGIRLTIAEERDKRLAAKQSSG</string>
                    <external_references type="UNIPROTKB">P62701</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="7">
                <name>Small ribosomal subunit protein uS7</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.022913453</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHG
RNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGARE
AAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR</string>
                    <external_references type="UNIPROTKB">P46782</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="8">
                <name>Small ribosomal subunit protein eS6</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.028751905999999997</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKG
HSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRK
PLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRAS
TSKSESSQK</string>
                    <external_references type="UNIPROTKB">P62753</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="9">
                <name>Small ribosomal subunit protein eS7</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.022168914</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLV
RELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDK
AQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL</string>
                    <external_references type="UNIPROTKB">P62081</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="10">
                <name>Small ribosomal subunit protein eS8</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.024263386999999997</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MGISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGGNKKYRALRLDVGNFSWGSECCTRKTRIID
VVYNASNNELVRTKTLVKNCIVLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISS
LLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRKIKARKGK</string>
                    <external_references type="UNIPROTKB">P62241</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="11">
                <name>Small ribosomal subunit protein uS4</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.022641563999999996</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAARELLTLDEKDPRRLFEGNALLRR
LVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFS
LRSPYGGGRPGRVKRKNAKKGQGGAGAGDDEEED</string>
                    <external_references type="UNIPROTKB">P46781</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="12">
                <name>Small ribosomal subunit protein eS10</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.018933846</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLR
DYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGR
GQPPQ</string>
                    <external_references type="UNIPROTKB">P46783</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="13">
                <name>Small ribosomal subunit protein uS17</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.018468826</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MADIQTERAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKM
KMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQIGDIVTVGECRPLSKTVRFNVLKVTKAAGTKKQFQKF</string>
                    <external_references type="UNIPROTKB">P62280</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="14">
                <name>Small ribosomal subunit protein eS12</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.014538986999999998</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MAEEGIAAGGVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPMYVKLVEALCAEHQINLIKVD
DNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFKCKK</string>
                    <external_references type="UNIPROTKB">P25398</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="15">
                <name>Small ribosomal subunit protein uS15</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.017259389</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGL
APDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA</string>
                    <external_references type="UNIPROTKB">P62277</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="16">
                <name>Small ribosomal subunit protein uS11</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.016302772</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MAPRKGKEKKEEQVISLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADRDESSPYAAMLAAQD
VAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL</string>
                    <external_references type="UNIPROTKB">P62263</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="17">
                <name>Small ribosomal subunit protein uS19</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.017076206999999996</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MAEVEQKKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLNRGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHL
RDMIILPEMVGSMVGVYNGKTFNQVEIKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLK</string>
                    <external_references type="UNIPROTKB">P62841</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="18">
                <name>Small ribosomal subunit protein uS9</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.016477377</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MPSKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAGVDIRVRVKGGGHVAQ
IYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFGGPGARARYQKSYR</string>
                    <external_references type="UNIPROTKB">P62249</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="19">
                <name>Small ribosomal subunit protein eS17</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.015578156000000001</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERER
RDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGPV</string>
                    <external_references type="UNIPROTKB">P08708</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="20">
                <name>Small ribosomal subunit protein uS13</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.017759776999999997</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPRQYKIP
DWFLNRQKDVKDGKYSQVLANGLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRTVGVSKKK</string>
                    <external_references type="UNIPROTKB">P62269</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="21">
                <name>Small ribosomal subunit protein eS19</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.016091562</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASTARHLYLRGGAGVGSMTKIYG
GRQRNGVMPSHFSRGSKSVARRVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKKH</string>
                    <external_references type="UNIPROTKB">P39019</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="22">
                <name>Small ribosomal subunit protein uS10</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.013398763000000001</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MAFKDTGKTPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTRKTPCGEGSKTWDRF
QMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIADA</string>
                    <external_references type="UNIPROTKB">P60866</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="23">
                <name>Small ribosomal subunit protein eS21</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.009124388999999998</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MQNDAGEFVDLYVPRKCSASNRIIGAKDHASIQMNVAEVDKVTGRFNGQFKTYAICGAIRRMGESDDSILRLAKADGIVS
KNF</string>
                    <external_references type="UNIPROTKB">P63220</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="24">
                <name>Small ribosomal subunit protein uS8</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.014865554999999999</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFD
VQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF</string>
                    <external_references type="UNIPROTKB">P62244</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="25">
                <name>40S ribosomal protein S23</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.015844665999999997</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKK
ITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS</string>
                    <external_references type="UNIPROTKB">P62266</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="26">
                <name>40S ribosomal protein S24</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.015463333</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLD
YAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKPKE</string>
                    <external_references type="UNIPROTKB">P62847</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="27">
                <name>Small ribosomal subunit protein eS25</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.013776224</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIR
GSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA</string>
                    <external_references type="UNIPROTKB">P62851</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="28">
                <name>Small ribosomal subunit protein eS26</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.013047531999999999</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MTKKRRNNGRAKKGRGHVQPIRCTNCARCVPKDKAIKKFVIRNIVEAAAVRDISEASVFDAYVLPKLYVKLHYCVSCAIH
SKVVRNRSREARKDRTPPPRFRPAGAAPRPPPKPM</string>
                    <external_references type="UNIPROTKB">P62854</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="29">
                <name>Small ribosomal subunit protein eS27</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.009480186</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MPLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFR
RKQH</string>
                    <external_references type="UNIPROTKB">P42677</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="30">
                <name>Small ribosomal subunit protein eS28</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.007855052</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MDTSRVQPIKLARVTKVLGRTGSQGQCTQVRVEFMDDTSRSIIRNVKGPVREGDVLTLLESEREARRLR</string>
                    <external_references type="UNIPROTKB">P62857</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="31">
                <name>Small ribosomal subunit protein uS14</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.006690821</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MGHQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFIKLD</string>
                    <external_references type="UNIPROTKB">P62273</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="32">
                <name>Small ribosomal subunit protein eS30</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.006668938</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>KVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPNANS</string>
                    <external_references type="UNIPROTKB">P62861</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="33">
                <name>Ubiquitin-ribosomal protein eS31 fusion protein</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.018004041000000002</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKR
KKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYCFNKPEDK</string>
                    <external_references type="UNIPROTKB">P62979</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="34">
                <name>Receptor of activated protein C kinase 1</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.035115652</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALS
GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNS
SNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC
FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR</string>
                    <external_references type="UNIPROTKB">P63244</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="35">
                <name>La-related protein 1</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.123705344</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <recombinant_expression database="NCBI">
                    <recombinant_organism ncbi="9606">Homo sapiens</recombinant_organism>
                </recombinant_expression>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MATQVEPLLPGGATLLQAEEHGGLVRKKPPPAPEGKGEPGPNDVRGGEPDGSARRPRPPCAKPHKEGTGQQERESPRPLQ
LPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDFVEAPPPKVNPWTKNALPPVLTTVNGQSPPEHSAPAKVVRAAVPK
QRKGSKVGDFGDAINWPTPGEIAHKSVQPQSHKPQPTRKLPPKKDMKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQR
GGQKKKGNKHKWVPLQIDMKPEVPREKLASRPTRPPEPRHIPANRGEIKGSESATYVPVAPPTPAWQPEIKPEPAWHDQD
ETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGVEGPRTPKYMNNITYYFDNVSSTELYSVDQ
ELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRRREEP
EKWPLPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIEV
KKRPRPSPARPKKSEESRFSHLTSLPQQLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTFTAWSDEESDYEIDDRDV
NKILIVTQTPHYMRRHPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWAEKFEPEYSQIKQEVENFKKVNMISREQF
DTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNTRTPRTPRTPQLKDSSQTSRF
YPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSPSEGTPTVGSYGCTPQSLPKFQHPSHELL
KENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSY
GLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRRLEDFRVDPPMGEEGNHKRHS
VVAGGGGGEGRKRCPSQSSSRPAAMISQPPTPPTGQPVREDAKWTSQHSNTQTLGK</string>
                    <external_references type="UNIPROTKB">Q6PKG0</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="36">
                <name>Small ribosomal subunit protein eS32</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.003473451</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>MRAKWRKKRMRRLKRKRRKMRQRSK</string>
                    <external_references type="UNIPROTKB">P62945</external_references>
                </sequence>
            </protein_or_peptide>
            <ligand macromolecule_id="37">
                <name>POTASSIUM ION</name>
                <molecular_weight>
                    <theoretical units="MDa">3.9098e-05</theoretical>
                </molecular_weight>
                <number_of_copies>71</number_of_copies>
                <formula>K</formula>
            </ligand>
            <ligand macromolecule_id="38">
                <name>MAGNESIUM ION</name>
                <molecular_weight>
                    <theoretical units="MDa">2.4305e-05</theoretical>
                </molecular_weight>
                <number_of_copies>92</number_of_copies>
                <formula>MG</formula>
            </ligand>
            <ligand macromolecule_id="39">
                <name>ZINC ION</name>
                <molecular_weight>
                    <theoretical units="MDa">6.5409e-05</theoretical>
                </molecular_weight>
                <number_of_copies>3</number_of_copies>
                <formula>ZN</formula>
            </ligand>
        </macromolecule_list>
    </sample>
    <structure_determination_list>
        <structure_determination structure_determination_id="1">
            <method>singleParticle</method>
            <aggregation_state>particle</aggregation_state>
            <specimen_preparation_list>
                <single_particle_preparation preparation_id="1">
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