2025-08-13 REL RCSB INITIAL_RELEASE REPOSITORY RCSB RCSB 2024-11-27 2025-08-13 2025-08-13 2025-08-13 Bill & Melinda Gates Foundation United States NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs [C4 Reconstruction] Borst AJ Neuraminidase, NCS.1.1, Tetramer, Antibody, Fab, N1, H1N5, CA09, VIRAL PROTEIN Lederhofer J Borst AJ Nguyen L Gillespie RA Williams CJ Walker EL Raab JE Yap C Ellis D Creanga A Tan HX Do THT Ravichandran M McDermott AB Le Sage V Andrews SF Graham BS Wheatley AK Reed DS King NP Kanekiyo M Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies. Nat Commun UK 16 7068 7068 2025 40750617 doi:10.1038/s41467-025-62339-z 2041-1723 9ejf FULLOVERLAP EMDB EMD-48102 associated EM volume
NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs
 NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs NCS.1.1 Fab in complex with the sNAp of A/California/04/2009 (CA09, H1N1) -- 4 Fabs 0 1 2 3 Homo sapiens Neuraminidase Influenza A virus 0.049139933999999996 4 Homo sapiens LEVO HHHHHHSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSLVPRGSGGVKLAGNSSLCPVSGWAPLSKDNS VRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSVPIGSVPSPYNARFESIAWSASACH DGINWLTIGITGPDNGAVAILKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVK SVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANG VKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVMHPELTGLDCIVPCFWVE LIRGRPKENTIWTSGSSISFCGVNSDTTGWSWPDGAELPFTIDK A0A024D2C1 3.2.1.18 NCS.1.1 Heavy Chain Homo sapiens 0.014012506 4 Homo sapiens LEVO QVQLQESGPRLVKPSETLSLTCSVSGESISSGGYYWTWIRQHPGKGLEWIGNIFDTGSTDYSPSLKTRLTISIDTSKNQF YLRLNSATAADTAVYYCARVGFSLETDRPYYLGLDVWGQGTTVTVSS NCS.1.1 Light Chain Homo sapiens 0.012252718999999999 4 Homo sapiens LEVO DIVMTQSPLSLPVTPGEPASISCRSSQSLLHSNGYTYLDWYLQKPGQSPQLLISFTSNRASGVPDRFSGSGSGTYFTLKI SRVEAEDVGVYYCMQAVQTPWTFGQGTKVEIK 2-acetamido-2-deoxy-beta-D-glucopyranose 0.000221208 8 NAG CALCIUM ION 4.0078e-05 8 CA water 1.8015e-05 918 HOH singleParticle particle 7.4 ETHANE TFS GLACIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 200 1.0 2.0 GATAN K3 (6k x 4k) 50.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION Ab initio 2.29 FSC 0.143 CUT-OFF 382836 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_48102.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 460 460 460 0 0 0 460 460 460 407.1 407.1 407.1 90.0 90.0 90.0 X Y Z -0.4460062 0.7034595 -0.000022895392 0.01450519 0.885 0.885 0.885 0.0656 AUTHOR Sharpened map FLEXIBLE FIT REAL emd_48102_additional_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 460 460 460 0 0 0 460 460 460 407.1 407.1 407.1 90.0 90.0 90.0 X Y Z -0.05029225 0.16815397 -0.000023918883 0.003632115 0.885 0.885 0.885 AUTHOR Unsharpened map emd_48102_additional_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 460 460 460 0 0 0 460 460 460 407.1 407.1 407.1 90.0 90.0 90.0 X Y Z -0.039927848 1.526292 0.0006649996 0.018232848 0.885 0.885 0.885 AUTHOR DeepEMhanced map emd_48102_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 460 460 460 0 0 0 460 460 460 407.1 407.1 407.1 90.0 90.0 90.0 X Y Z -0.054304242 0.18436979 0.00008762554 0.0048263576 0.885 0.885 0.885 AUTHOR Half B emd_48102_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 460 460 460 0 0 0 460 460 460 407.1 407.1 407.1 90.0 90.0 90.0 X Y Z -0.05723807 0.17586944 0.00008721044 0.004818821 0.885 0.885 0.885 AUTHOR Half A