2026-02-25 REL RCSB INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY RCSB RCSB 2025-02-24 2026-02-18 2026-02-18 2026-02-25 Not funded CryoEM Structure of PHR-phosphatase-C2 domain of SHIP2 Gupta J Izard T inositol phosphatase, LIPID BINDING PROTEIN Gupta J Le Coq J Lietha D Izard T Structural insights into SHIP2 reveal its membrane regulatory mechanisms. Protein Sci. US 35 e70479 e70479 2026 41676923 doi:10.1002/pro.70479 1469-896X 0795 PRCIEI EMDB EMD-49401 associated EM volume PHR-phosphatase-C2 domains of SHIP2 PHR-phosphatase-C2 domains of SHIP2 0 1 Homo sapiens 0.068 singleParticle particle 0.2 7.5 ETHANE JEOL CRYO ARM 300 FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 2.7 0.8 2.4 JEOL CRYOSPECPORTER NITROGEN OTHER GATAN K3 (6k x 4k) 48.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 5.4 FSC 0.143 CUT-OFF cryoSPARC 513600 OTHER OTHER emd_49401.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 128 128 128 0 0 0 128 128 128 184.32 184.32 184.32 90.0 90.0 90.0 X Y Z -0.90927047 0.8941236 -0.00054871675 0.03691951 1.44 1.44 1.44 0.0877 AUTHOR Coulomb potential map for SHIP2 PHR-PTase-C2 emd_49401_msk_1.map emd_49401_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 128 128 128 0 0 0 128 128 128 184.32 184.32 184.32 90.0 90.0 90.0 X Y Z -0.6494785 0.4566542 0.00027427624 0.029277418 1.44 1.44 1.44 AUTHOR Half Map A emd_49401_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 128 128 128 0 0 0 128 128 128 184.32 184.32 184.32 90.0 90.0 90.0 X Y Z -0.5520606 0.4528613 0.00028264776 0.029388165 1.44 1.44 1.44 AUTHOR Half Map B