2026-03-25 REL RCSB INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY DATABASE_REFERENCES citation em_admin _citation.journal_volume _citation.page_first _citation.year _em_admin.last_update EXPERIMENTAL_SUMMARY citation em_admin _citation.journal_volume _citation.page_first _citation.year _em_admin.last_update RCSB RCSB 2025-03-25 2026-02-04 2026-02-04 2026-03-25 National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) NS120496 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) U24GM129547 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM136430 United States Muscle-type nicotinic acetylcholine receptor bound to conotoxin ImII Stowell MHB Hibbs RE Noviello CM Bhattacharjee B ion channel, toxin, MEMBRANE PROTEIN Bhattacharjee B Noviello CM Rahman MM Mayer JP Gajewiak J McIntosh JM Hibbs RE Stowell MHB Shape-shifting conotoxins reveal divergent pore-targeting mechanisms in nicotinic receptors. Structure UK 34 463 2026 41468893 doi:10.1016/j.str.2025.12.003 0969-2126 2005 STRUE6 9nx2 FULLOVERLAP EMDB EMD-49899 associated EM volume
Muscle-type nicotinic acetylcholine receptor bound to conotoxin ImII
 Complex of conotoxin ImII and human muscle-type nicotinic acetyclcholine receptor Complex of conotoxin ImII and human muscle-type nicotinic acetyclcholine receptor 0 1 2 3 4 5 Human muscle-type nicotinic acetyclcholine receptor 1 1 2 3 4 Tetronarce californica Conotoxin ImII 1 5 Conus imperialis Acetylcholine receptor subunit alpha Tetronarce californica 0.049869895 2 LEVO SEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQLIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRL PSDDVWLPDLVLYNNADGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKVSISP ESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVVNVIIPCLLFSFLTGLVFYLPTDSG EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTI PNVMFFSTMKRASKEKQENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAAEEWK YVAMVIDHILLCVFMLICIIGTVSVFAGRKIELS P02710 Acetylcholine receptor subunit delta Tetronarce californica 0.0574555 1 LEVO NEEERLINDLLIVNKYNKHVRPVKHNNEVVNIALSLTLSNLISLKETDETLTSNVWMDHAWYDHRLTWNASEYSDISILR LPPELVWIPDIVLQNNNDGQYHVAYFCNVLVRPNGYVTWLPPAIFRSSCPINVLYFPFDWQNCSLKFTALNYDANEITMD LMTDTIDGKDYPIEWIIIDPEAFTENGEWEIIHKPAKKNIYPDKFPNGTNYQDVTFYLIIRRKPLFYVINFITPCVLISF LASLAFYLPAESGEKMSTAISVLLAQAVFLLLTSQRLPETALAVPLIGKYLMFIMSLVTGVIVNCGIVLNFHFRTPSTHV LSTRVKQIFLEKLPRILHMSRADESEQPDWQNDLKLRRSSSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPRIG FGNNNENIAASDQLHDEIKSGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMFIITPVMVLGTIFIFVMGNFNHP PAKPFEGDPFDYSSDHPRC P02718 Acetylcholine receptor subunit beta Tetronarce californica 0.053731773 1 LEVO SVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLTLTNLLILNEKIEEMTTNVFLNLAWTDYRLQWDPAAYEGIKDLRI PSSDVWQPDIVLMNNNDGSFEITLHVNVLVQHTGAVSWQPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEVTLQH ALDAKGEREVKEIVINKDAFTENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRKPLFYIVYTIIPCILISILAILVFY LPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLSVPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQ IFIETLPPFLWIQRPVTTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVTLPQD LKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFLDASHNVPPDNPFA P02712 Acetylcholine receptor subunit gamma Tetronarce californica 0.056335684 1 LEVO ENEEGRLIEKLLGDYDKRIIPAKTLDHIIDVTLKLTLTNLISLNEKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRI PSELLWLPDVVLENNVDGQFEVAYYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQL SAEEGEAVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDTDFQEIIFFLIIQRKPLFYIINIIAPCVLISSLVVLV YFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLIGKYLIFVMFVSMLIVMNCVIVLNVSLRTPNTHSLSEK IKHLFLGFLPKYLGMQLEPSEETPEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTV DLYKDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSIGTLAIFLTGHFNQVPEFPF PGDPRKYVP P02714 Alpha-conotoxin ImII Conus imperialis 0.001516822 2 LEVO ACCSDRRCRWRC(NH2) Q8I6R5 2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYLETHANAMINIUM 0.00014719499999999998 2 CCE 2-acetamido-2-deoxy-beta-D-glucopyranose 0.000221208 2 NAG water 1.8015e-05 5 HOH singleParticle particle 7.4 ETHANE TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 2.7 5.0 5.0 30.0 GATAN K2 SUMMIT (4k x 4k) SUPER-RESOLUTION 50.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 2.96 FSC 0.143 CUT-OFF cryoSPARC 128448 COMMON LINE MAXIMUM LIKELIHOOD emd_49899.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 261.6 261.6 261.6 90.0 90.0 90.0 X Y Z -0.04761855 0.12691306 0.00056125637 0.004773368 0.87200004 0.87200004 0.87200004 0.02 AUTHOR 7KOO PDB experimental model FLEXIBLE FIT emd_49899_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 261.6 261.6 261.6 90.0 90.0 90.0 X Y Z -0.0767114 0.14160128 0.0003790609 0.009846429 0.87200004 0.87200004 0.87200004 AUTHOR Half Map B emd_49899_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 261.6 261.6 261.6 90.0 90.0 90.0 X Y Z -0.07460424 0.15367469 0.0003763873 0.009831198 0.87200004 0.87200004 0.87200004 AUTHOR Half Map A