2026-02-11 REL PDBe INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY PDBe PDBe 2025-03-16 2026-02-11 2026-02-11 2026-02-11 Not funded Cryo-EM structure of mouse TRPM3 alpha 2 in complex with antagonist Isosakuranetin Shkumatov AV Schenck S Brunner JD Ca2+ channel, Isosakuranetin-bound Closed conformation, MEMBRANE PROTEIN Shkumatov AV Schenck S Brunner JD Cryo-EM structure of mouse TRPM3 alpha 2 in complex with antagonist Isosakuranetin To Be Published 0353 EMD-53174 other EM volume
Cryo-EM structure of mouse TRPM3 alpha 2 in APO state
 EMD-53175 other EM volume
Cryo-EM structure of mouse TRPM3 alpha 2 in complex with antagonist Primidone
 EMD-53173 other EM volume
Cryo-EM structure of mouse TRPM3 alpha 2 in complex with antagonist Ononetin
 EMD-53177 other EM volume
Cryo-EM structure of mouse TRPM3 alpha 2 in with agonists CIM-0216 and Pregnenolone sulfate (PregS)
 9qhp FULLOVERLAP EMDB EMD-53174 other EM volume
Cryo-EM structure of mouse TRPM3 alpha 2 in APO state
 EMDB EMD-53175 other EM volume
Cryo-EM structure of mouse TRPM3 alpha 2 in complex with antagonist Primidone
 EMDB EMD-53173 other EM volume
Cryo-EM structure of mouse TRPM3 alpha 2 in complex with antagonist Ononetin
 EMDB EMD-53177 other EM volume
Cryo-EM structure of mouse TRPM3 alpha 2 in with agonists CIM-0216 and Pregnenolone sulfate (PregS)
 EMDB EMD-53176 associated EM volume
Cryo-EM structure of mouse TRPM3 alpha 2 in complex with antagonist Isosakuranetin
 PDB 9QHN unspecified
Cryo-EM structure of mouse TRPM3 alpha 2 in APO state
 PDB 9QHO unspecified
Cryo-EM structure of mouse TRPM3 alpha 2 in complex with antagonist Primidone
 PDB 9QHM unspecified
Cryo-EM structure of mouse TRPM3 alpha 2 in complex with antagonist Ononetin
 PDB 9QHQ unspecified
Cryo-EM structure of mouse TRPM3 alpha 2 in with agonists CIM-0216 and Pregnenolone sulfate (PregS)
 Tetrameric assembly of mouse TRPM3 alpha 2 with inhibitor Isosakuranetin Tetrameric assembly of mouse TRPM3 alpha 2 with inhibitor Isosakuranetin 0 1 Mus musculus 0.161 MKIAA1616 protein Mus musculus 0.16196325 4 Homo sapiens LEVO MSGKKWRDAGELERGCSDREDSAESRRRSRSASRGRFAESWKRLSSKQGSTKRSGLPAQQTPAQKSWIERAFYKRECVHI IPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVR VSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKD HASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHI SLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTI QKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIY GQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLID IGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFH ELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQ LAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMP YMTQAQEIHLQEKEPEEPEKPTKEKDEEDMELTAMLGRSNGESSRKKDEEEVQSRHRLIPVGRKIYEFYNAPIVKFWFYT LAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI LRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPS WKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKTIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFF EVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHVCCRWRKHESDQDERDYGLKLFITDDELKKVHDFEEQ CIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAE SNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETISPTSPTLMPRMRSHSFYSVALEVLFQGPQGTEQK LISEEDLRGASMDEKTTGWRGGHVVEGLAGELEQLRARLEHHPQGQREP Q69ZE8 (2~{R})-2-(4-methoxyphenyl)-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one 0.00028627899999999996 4 A1JBK (25R)-14beta,17beta-spirost-5-en-3beta-ol 0.00041462099999999995 8 YUV singleParticle particle 0.3 7.5 10.0 C8H17N2NaO4S Hepes 150.0 NaCl Sodium chloride 0.0063 C56H92O25 Glycodiosgenin 10.0 C16H14O5 Isosakuranetin
10 mM Hepes pH 7.5, 150 mM NaCl, 0.063% Glycodiosgenin, 10 uM Isosakuranetin
 Quantifoil R2/1 GOLD 300 GRAPHENE CONTINUOUS GLOW DISCHARGE ETHANE 90 279.15 LEICA EM GP
GP2.
JEOL CRYO ARM 300 FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 0.7000000000000001 1.0 GATAN K3 (6k x 4k) 62.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 2.35 FSC 0.143 CUT-OFF 281282 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_53176.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 500 500 500 0 0 0 500 500 500 347.0 347.0 347.0 90.0 90.0 90.0 X Y Z -0.03892499 0.10810857 0.00020006445 0.002852034 0.694 0.694 0.694 0.02 AUTHOR Cryo-EM structure of mouse TRPM3 alpha 2 in complex with Isosakuranetin emd_53176_msk_1.map emd_53176_additional_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 500 500 500 0 0 0 500 500 500 347.0 347.0 347.0 90.0 90.0 90.0 X Y Z -0.001848521 1.7074449 0.0012689937 0.023732953 0.694 0.694 0.694 AUTHOR DeepEMhancer map used for model building and phenix validation emd_53176_additional_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 500 500 500 0 0 0 500 500 500 347.0 347.0 347.0 90.0 90.0 90.0 X Y Z -0.1974047 0.31689397 0.00020006447 0.006236834 0.694 0.694 0.694 AUTHOR Sharpened map used for model building emd_53176_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 500 500 500 0 0 0 500 500 500 347.0 347.0 347.0 90.0 90.0 90.0 X Y Z -0.053277384 0.12034134 0.00019209282 0.0046631643 0.694 0.694 0.694 AUTHOR half B emd_53176_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 500 500 500 0 0 0 500 500 500 347.0 347.0 347.0 90.0 90.0 90.0 X Y Z -0.07609864 0.11862936 0.00019351413 0.004673458 0.694 0.694 0.694 AUTHOR half A