2026-03-04 REL PDBe INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY DATABASE_REFERENCES citation citation_author em_admin _citation.journal_volume _citation.page_first _citation.page_last _citation_author.identifier_ORCID _em_admin.last_update EXPERIMENTAL_SUMMARY citation citation_author em_admin _citation.journal_volume _citation.page_first _citation.page_last _citation_author.identifier_ORCID _em_admin.last_update PDBe PDBe 2025-03-25 2026-02-18 2026-02-18 2026-03-04 Lundbeckfonden R368-2021-522 Denmark Novo Nordisk Foundation NNF21OC0067835 Denmark Novo Nordisk Foundation NFF20OC0065017 Denmark Other government 1026-00335B Denmark Inward-open structure of human GABA transporter 3 bound to selective inhibitor SR-THAP Mortensen JS Bavo F Jensen MH Pedersen APS Storm JP Pape T Frolund B Wellendorph P Shahsavar A Transport protein, SLC6A11, neurotransmitter/sodium symporter, Sodium- and chloride-dependent GABA transporter 3, GAT3, MEMBRANE PROTEIN Mortensen JS Bavo F Jensen MH Pedersen APS Storm JP Pape T Frolund B Wellendorph P Shahsavar A Structural basis for selective inhibition of human GABA transporter GAT3. Nat Commun UK 17 1774 1774 2026 41611703 doi:10.1038/s41467-026-68479-0 2041-1723 9qo8 FULLOVERLAP PDB 9QO9 unspecified
D_1292146614 contains the same protein but bound to substrate GABA
 PDB 9QOA unspecified
D_1292146640 contains the same protein but in substrate-free state
 EMDB EMD-53259 associated EM volume
Inward-open structure of human GABA transporter 3 bound to selective inhibitor SR-THAP
 Human GABA transporter 3 bound to selective inhibitor SR-THAP Human GABA transporter 3 bound to selective inhibitor SR-THAP 0 1 Homo sapiens 0.07 Sodium- and chloride-dependent GABA transporter 3 Homo sapiens 0.07066043799999999 1 Homo sapiens LEVO MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLC YKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSN CFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICY FCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTAL GSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFF MMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVA IFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALS SMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF P48066 (2S, 2'R)-2-hydroxy-2-(1-((E)-4,4,4-tris(4-methoxyphenyl)but-2-en-1-yl)pyrrolidin-2'-yl)acetic acid 0.000517613 1 A1I87 CHLORIDE ION 3.5453e-05 1 CL water 1.8015e-05 7 HOH singleParticle particle 4 7.5 Quantifoil GOLD 300 GOLD GLOW DISCHARGE ETHANE 100 277.15 TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 2.7 0.6 1.8 165000.0 FEI TITAN KRIOS AUTOGRID HOLDER NITROGEN TFS Selectris X 10 FEI FALCON IV (4k x 4k) 1 44460 3.3 60.0 1 NONE
AF-P48066-F1-v4
 2.9 FSC 0.143 CUT-OFF cryoSPARC 4.6.2 139776 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_53259.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 320 320 320 0 0 0 320 320 320 233.28 233.28 233.28 90.0 90.0 90.0 X Y Z -0.4366391 0.5899139 0.000021864325 0.013676167 0.729 0.729 0.729 0.0635 AUTHOR cryo-EM map AF-P48066-F1-v4 AlphaFold in silico model emd_53259_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 320 320 320 0 0 0 320 320 320 233.28 233.28 233.28 90.0 90.0 90.0 X Y Z -0.22973974 0.25339013 0.00016833165 0.02932373 0.729 0.729 0.729 AUTHOR Half map A emd_53259_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 320 320 320 0 0 0 320 320 320 233.28 233.28 233.28 90.0 90.0 90.0 X Y Z -0.2202938 0.24900049 0.00016552997 0.029151084 0.729 0.729 0.729 AUTHOR Half map B