2026-02-18 REL PDBe INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY PDBe PDBe 2025-04-09 2026-02-18 2026-02-18 2026-02-18 European Research Council (ERC) 788974 European Union Agence Nationale de la Recherche (ANR) ANR-23-CE11-0009-01 France Human alpha7 nicotinic receptor in complex with the E6 nanobody Barilone N Vangelatou M Marouf FZ Dejean de la Batie G Ayme G Lafaye P Corringer P-J Prevost MS Nicotinic receptor, Nanobody, MEMBRANE PROTEIN Barilone N Vangelatou M Marouf FZ Dejean de la Batie G Li Q Lafaye P Ayme G Corringer PJ Prevost MS Discovery and mechanism of negative allosteric modulation of the alpha 7 nicotinic acetylcholine receptor by nanobodies. Proc.Natl.Acad.Sci.USA US 123 e2514734123 e2514734123 2026 41576092 doi:10.1073/pnas.2514734123 1091-6490 0040 PNASA6 9qto FULLOVERLAP EMDB EMD-53356 associated EM volume
Human alpha7 nicotinic receptor in complex with the E6 nanobody
 Human nicotinic acetylcholine receptor alpha7 in complex with Nanobody E6 Human nicotinic acetylcholine receptor alpha7 in complex with Nanobody E6 0 1 2 Homo sapiens 0.325 Neuronal acetylcholine receptor subunit alpha-7,CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion Homo sapiens 0.04283766 5 Homo sapiens LEVO EFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFP DGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKIS LGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFL RMKRDGVAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA P36544 A0A0A6YYA8 Nanobody E6 Vicugna pacos 0.017089727 5 Escherichia coli LEVO AQLQLVESGGGLVQPGGSLRLSCAASGFTLDYYTIGWFRQAPGKEREGVSCIRGSGGSTNYADSVKGRFTISRDNAKNTV YLQMNSLKPEDTAVYYCAADFLSTCSLAGYRYEEVWGQGTLVTVSSAHHSEDPSAAAEQKLISEEDLNGAAHHHHHHGS water 1.8015e-05 292 HOH singleParticle particle 0.7 7.8 UltrAuFoil R1.2/1.3 GOLD 300 GLOW DISCHARGE ETHANE TFS TITAN THEMIS OTHER OTHER FIELD EMISSION GUN 300 0.7000000000000001 2.75 GATAN K3 BIOQUANTUM (6k x 4k) 30.0 1 NONE 2.16 FSC 0.143 CUT-OFF 445239 ANGULAR RECONSTITUTION ANGULAR RECONSTITUTION emd_53356.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 450 450 450 0 0 0 450 450 450 290.25 290.25 290.25 90.0 90.0 90.0 X Y Z -0.19038609 0.47082907 0.00020871157 0.012151429 0.645 0.645 0.645 0.08 AUTHOR RIGID BODY FIT emd_53356_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 450 450 450 0 0 0 450 450 450 290.25 290.25 290.25 90.0 90.0 90.0 X Y Z -0.54320556 0.6117943 0.00030368555 0.062656365 0.645 0.645 0.645 AUTHOR emd_53356_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 450 450 450 0 0 0 450 450 450 290.25 290.25 290.25 90.0 90.0 90.0 X Y Z -0.49641082 0.5783553 0.0003057798 0.06251385 0.645 0.645 0.645 AUTHOR