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        <grant_support>
            <grant_reference>
                <funding_body>Not funded</funding_body>
            </grant_reference>
        </grant_support>
        <title>S315N KatG mutant no heme</title>
        <authors_list>
            <author>Chaplin A</author>
            <author>Allport T</author>
        </authors_list>
        <keywords>Catalase, Peoxidase, Enzyme, Heme, METAL BINDING PROTEIN</keywords>
    </admin>
    <crossreferences>
        <citation_list>
            <primary_citation>
                <journal_citation published="true">
                    <author order="1">Allport T</author>
                    <author ORCID="0000-0002-9606-8346" order="2">Chaplin AK</author>
                    <title>Uncovering the structural impact of KatG Ser315 mutations in Mycobacterium tuberculosis via cryo-EM.</title>
                    <journal_abbreviation>Protein Sci.</journal_abbreviation>
                    <country>US</country>
                    <volume>35</volume>
                    <first_page>e70409</first_page>
                    <last_page>e70409</last_page>
                    <year>2026</year>
                    <external_references type="PUBMED">41432360</external_references>
                    <external_references type="DOI">doi:10.1002/pro.70409</external_references>
                    <external_references type="ISSN">1469-896X</external_references>
                    <external_references type="CSD">0795</external_references>
                    <external_references type="ASTM">PRCIEI</external_references>
                </journal_citation>
            </primary_citation>
        </citation_list>
        <pdb_list>
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                <pdb_id>9sgr</pdb_id>
                <relationship>
                    <in_frame>FULLOVERLAP</in_frame>
                </relationship>
            </pdb_reference>
        </pdb_list>
        <other_db_list>
            <db_reference>
                <db_name>PDB</db_name>
                <accession_id>9SGL</accession_id>
                <content_type>unspecified</content_type>
                <details>KatG S315T two heme</details>
            </db_reference>
            <db_reference>
                <db_name>PDB</db_name>
                <accession_id>9SGM</accession_id>
                <content_type>unspecified</content_type>
                <details>KatG S315I two heme</details>
            </db_reference>
            <db_reference>
                <db_name>PDB</db_name>
                <accession_id>9SGN</accession_id>
                <content_type>unspecified</content_type>
                <details>KatG S315I no heme</details>
            </db_reference>
            <db_reference>
                <db_name>PDB</db_name>
                <accession_id>9SGO</accession_id>
                <content_type>unspecified</content_type>
                <details>KatG S315N one heme</details>
            </db_reference>
            <db_reference>
                <db_name>PDB</db_name>
                <accession_id>9SGP</accession_id>
                <content_type>unspecified</content_type>
                <details>KatG S315R two heme</details>
            </db_reference>
            <db_reference>
                <db_name>PDB</db_name>
                <accession_id>9SGQ</accession_id>
                <content_type>unspecified</content_type>
                <details>KatG S315R one heme</details>
            </db_reference>
            <db_reference>
                <db_name>PDB</db_name>
                <accession_id>9SGY</accession_id>
                <content_type>unspecified</content_type>
                <details>KatG S315I one heme</details>
            </db_reference>
            <db_reference>
                <db_name>PDB</db_name>
                <accession_id>9SGS</accession_id>
                <content_type>unspecified</content_type>
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    </crossreferences>
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        <name>KatG</name>
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                <parent>0</parent>
                <macromolecule_list>
                    <macromolecule>
                        <macromolecule_id>1</macromolecule_id>
                    </macromolecule>
                </macromolecule_list>
                <natural_source database="NCBI">
                    <organism ncbi="1773">Mycobacterium tuberculosis</organism>
                </natural_source>
            </complex_supramolecule>
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        <macromolecule_list>
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                <name>Catalase-peroxidase</name>
                <natural_source database="NCBI">
                    <organism ncbi="1773">Mycobacterium tuberculosis</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.084096258</theoretical>
                </molecular_weight>
                <number_of_copies>2</number_of_copies>
                <recombinant_expression database="NCBI">
                    <recombinant_organism ncbi="562">Escherichia coli</recombinant_organism>
                </recombinant_expression>
                <enantiomer>LEVO</enantiomer>
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                    <string>HHHHHHNTSGSGGGGGRLBPRGSMSENLYFQGMPEQHPPITETTTGAASNGCPVVGHMKYPVEGGGNQDWWPNRLNLKVL
HQNPAVADPMGAAFDYAAEVATIDVDALTRDIEEVMTTSQPWWPADYGHYGPLFIRMAWHAAGTYRIHDGRGGAGGGMQR
FAPLNSWPDNASLDKARRLLWPVKKKYGKKLSWADLIVFAGNCALESMGFKTFGFGFGRVDQWEPDEVYWGKEATWLGDE
RYSGKRDLENPLAAVQMGLIYVNPEGPNGNPDPMAAAVDIRETFRRMAMNDVETAALIVGGHTFGKTHGAGPADLVGPEP
EAAPLEQMGLGWKSSYGTGTGKDAITNGIEVVWTNTPTKWDNSFLEILYGYEWELTKSPAGAWQYTAKDGAGAGTIPDPF
GGPGRSPTMLATDLSLRVDPIYERITRRWLEHPEELADEFAKAWYKLIHRDMGPVARYLGPLVPKQTLLWQDPVPAVSHD
LVGEAEIASLKSQIRASGLTVSQLVSTAWAAASSFRGSDKRGGANGGRIRLQPQVGWEVNDPDGDLRKVIRTLEEIQESF
NSAAPGNIKVSFADLVVLGGCAAIEKAAKAAGHNITVPFTPGRTDASQEQTDVESFAVLEPKADGFRNYLGKGNPLPAEY
MLLDKANLLTLSAPEMTVLVGGLRVLGANYKRLPLGVFTEASESLTNDFFVNLLDMGITWEPSPADDGTYQGKDGSGKVK
WTGSRVDLVFGSNSELRALVEVYGADDAQPKFVQDFVAAWDKVMNLDRFDVR</string>
                    <external_references type="UNIPROTKB">A5U3S7</external_references>
                </sequence>
                <ec_number>1.11.1.21</ec_number>
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                    <nominal_cs units="mm">2.7</nominal_cs>
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