2025-12-10 REL PDBe INITIAL_RELEASE REPOSITORY PDBe PDBe 2025-10-02 2025-12-10 2025-12-10 2025-12-10 Ministerio de Ciencia e Innovacion (MCIN) PID2023-149259NB-I00, Spain European Regional Development Fund PID2023-149259NB-I00 European Union Agencia Estatal de Investigacion (AEI) PID2023-149259NB-I00 Spain Consejo Nacional de Ciencia y Tecnologia (CONACYT) 773992 Mexico Engineering and Physical Sciences Research Council EP/W524372/1 United Kingdom Wellcome Trust 220628/Z/20/Z United Kingdom Wellcome Trust 221524/Z/20/Z United Kingdom Wellcome Trust 223810/Z/21/Z United Kingdom Wolfson Foundation PR/jw/md/22597 United Kingdom Herpes simplex virus 2 delta28-73 glycoprotein C ectodomain in complex with C3b Rojas Rechy MH Atanasiu D Hook LM Cairns MT Saw WT Cahill A Guo Z Calabrese AN Ranson NA Friedman HM Cohen GH Fontana J Protein complex, domains 1 and 2 of gC2 with C3b., VIRAL PROTEIN Rojas Rechy MH Atanasiu D Hook LM Cairns TM Saw WT Cahill A Guo Z Calabrese AN Ranson NA Friedman HM Cohen GH Fontana J Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3b. Biorxiv US 2025 41256425 doi:10.1101/2025.10.04.680448 2692-8205 9sv8 FULLOVERLAP EMDB EMD-55245 associated EM volume
Herpes simplex virus 2 delta28-73 glycoprotein C ectodomain in complex with C3b
 Glycoprotein C of Herpes Simplex Virus, domains 1 and 2 with human complement protein C3b. Glycoprotein C of Herpes Simplex Virus, domains 1 and 2 with human complement protein C3b. 0 1 2 3
Glycoprotein C has a deletion in the amino-acids 28-73
Human alphaherpesvirus 2 0.180 Herpes simplex virus 2, delta28-73 glycoprotein C ectodomain 1 1
gC2 has a deletion in the amino-acids 28-73
Human alphaherpesvirus 2 Complement human protein C3b 1 2 3
Chains A and B from complement protein C3b.
Homo sapiens Envelope glycoprotein C Human alphaherpesvirus 2 0.051729296999999994
The gC2 ectodomain used contains a deletion from the amino-acids 28-73
1 Cricetulus griseus LEVO MALGRVGLTVGLWGLLWVGVVVVLANASPGRTITVGPRGNASNAAPSVPRNRSAPRTTPTPPQPRKATKSKASTAKPAPP PKTGPPKTSSEPVRCNRHDPLARYGSRVQIRCRFPNSTRTESRLQIWRYATATDAEIGTAPSLEEVMVNVSAPPGGQLVY DSAPNRTDPHVIWAEGAGPGASPRLYSVVGPLGRQRLIIEELTLETQGMYYWVWGRTDRPSAYGTWVRVRVFRPPSLTIH PHAVLEGQPFKATCTAATYYPGNRAEFVWFEDGRRVFDPAQIHTQTQENPDGFSTVSTVTSAAVGGQGPPRTFTCQLTWH RDSVSFSRRNASGTASVLPRPTITMEFTGDHAVCTAGCVPEGVTFAWFLGDDSSPAEKVAVASQTSCGRPGTATIRSTLP VSYEQTEYICRLAGYPDGIPVLEHHGSHQPPPRDPTERQVIRAVEGAGIGVAVLVAVVLAGTAVVYLTHASSVRYRRLR P03173 Complement C3 beta chain Homo sapiens 0.07140935899999999 1 Homo sapiens LEVO SPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGR NKFVTVQATFGTQVVEKVVLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSLSS QNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKGLEVTITARFLYG KKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNLRAEDLVGKSLYVSATVILHSGSDMVQAE RSGIPIVTSPYQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSI TVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLK AGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMT LKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQC PQPAA P01024 Complement C3b alpha' chain Homo sapiens 0.10407414799999999 1 Homo sapiens LEVO SNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQD FFIDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQ EVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVA QMTEDAVDAERLKHLIVTPSGCGEENMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAA FVKRAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVL ISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLY NVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKIT HRIHWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDAKNTMILEI CTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFN VELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTR LVKVQLSNDFDEYIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSYIIGKDTWV EHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN P01024 singleParticle particle 7.4 ETHANE TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 0.9 2.7 FEI FALCON IV (4k x 4k) 46.0 1 CTFFIND 4.1 PHASE FLIPPING AND AMPLITUDE CORRECTION 3.56 FSC 0.143 CUT-OFF cryoSPARC 4.6.2 466599 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_55245.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 222.0 222.0 222.0 90.0 90.0 90.0 X Y Z -1.4427714 2.3471453 0.0044899704 0.05067087 0.74 0.74 0.74 0.249 AUTHOR emd_55245_msk_1.map emd_55245_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 222.0 222.0 222.0 90.0 90.0 90.0 X Y Z -0.23120202 0.5656371 0.0025313697 0.026325557 0.74 0.74 0.74 AUTHOR emd_55245_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 222.0 222.0 222.0 90.0 90.0 90.0 X Y Z -0.24093798 0.55939233 0.002520135 0.02629319 0.74 0.74 0.74 AUTHOR