2026-02-11 REL PDBe INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY PDBe PDBe 2025-11-17 2026-02-11 2026-02-11 2026-02-11 Not funded Cryo-EM composite structure of mouse TRPM3 alpha 2 in complex with antagonist Ononetin Shkumatov AV Schenck S Brunner JD Ca2+ channel Ononetin-bound Closed conformation, MEMBRANE PROTEIN Shkumatov AV Schenck S Brunner JD Cryo-EM composite structure of mouse TRPM3 alpha 2 in complex with antagonist Ononetin To Be Published 0353 EMD-53173 consensus EM volume
Cryo-EM structure of mouse TRPM3 alpha 2 in complex with antagonist Ononetin
 EMD-55736 focused EM volume
Focused refinement map on N-terminus of mouse TRPM3 alpha 2 in complex with antagonist Ononetin
 9t9u FULLOVERLAP EMDB EMD-53173 consensus EM volume
Cryo-EM structure of mouse TRPM3 alpha 2 in complex with antagonist Ononetin
 EMDB EMD-55736 focused EM volume
Focused refinement map on N-terminus of mouse TRPM3 alpha 2 in complex with antagonist Ononetin
 EMDB EMD-55737 associated EM volume
Cryo-EM composite structure of mouse TRPM3 alpha 2 in complex with antagonist Ononetin
 Tetrameric assembly of mouse TRPM3 alpha 2 with inhibitor Ononetin Tetrameric assembly of mouse TRPM3 alpha 2 with inhibitor Ononetin 0 1 Mus musculus 0.161 MKIAA1616 protein Mus musculus 0.16196325 4 Homo sapiens LEVO MSGKKWRDAGELERGCSDREDSAESRRRSRSASRGRFAESWKRLSSKQGSTKRSGLPAQQTPAQKSWIERAFYKRECVHI IPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVR VSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKD HASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHI SLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTI QKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIY GQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLID IGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFH ELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQ LAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMP YMTQAQEIHLQEKEPEEPEKPTKEKDEEDMELTAMLGRSNGESSRKKDEEEVQSRHRLIPVGRKIYEFYNAPIVKFWFYT LAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI LRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPS WKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKTIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFF EVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHVCCRWRKHESDQDERDYGLKLFITDDELKKVHDFEEQ CIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAE SNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETISPTSPTLMPRMRSHSFYSVALEVLFQGPQGTEQK LISEEDLRGASMDEKTTGWRGGHVVEGLAGELEQLRARLEHHPQGQREP Q69ZE8 1-[2,4-bis(oxidanyl)phenyl]-2-(4-methoxyphenyl)ethanone 0.000258269 4 A1D6M 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE 0.000704998 4 3PH (25R)-14beta,17beta-spirost-5-en-3beta-ol 0.00041462099999999995 8 YUV singleParticle particle 0.3 7.5 10.0 C8H17N2NaO4S Hepes 150.0 NaCl Sodium chloride 0.0063 C56H92O25 Glycodiosgenin 10.0 C15H14O4 Ononetin
10 mM Hepes pH 7.5, 150 mM NaCl, 0.063% Glycodiosgenin, 10 uM Ononetin
 Quantifoil R2/1 GOLD 300 GRAPHENE CONTINUOUS ETHANE 90 279.15 LEICA EM GP
GP2.
JEOL CRYO ARM 300 FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 0.7000000000000001 1.0 GATAN K3 (6k x 4k) 62.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 8DDS 2.61 FSC 0.143 CUT-OFF PHENIX 309057 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_55737.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 500 500 500 0 0 0 500 500 500 346.5 346.5 346.5 90.0 90.0 90.0 Z Y X -57.742503999999997 80.426383999999999 -0.0128396945 1.0571933 0.693 0.693 0.693 4.46 AUTHOR Composite map of mouse TRPM3 alpha 2 in complex with antagonist Ononetin