2026-02-18 REL PDBe INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY PDBe PDBe 2025-12-10 2026-02-18 2026-02-18 2026-02-18 Medical Research Council (MRC, United Kingdom) MC_UP_1201/25 United Kingdom TAF15 amyloid filament fold C variant 2 Tetter S Varghese NR Ryskeldi-Falcon B Amyloid Neurodegeneration Frontotemporal lobar degeneration, PROTEIN FIBRIL Tetter S Varghese NR Murzin AG De Coster W Van den Broeck M Roeber S Joseph JT Newell K Castellani R Das S Ang LC Synofzik M Herms J Rademakers R Ghetti B Lashley T Mackenzie IRA Neumann M Ryskeldi-Falcon B Distinct TAF15 amyloid filament folds define multiple subtypes of FTLD-TAF15. Biorxiv US 2026 41648099 doi:10.64898/2026.01.12.698957 2692-8205 9tl2 FULLOVERLAP EMDB EMD-56041 associated EM volume
TAF15 amyloid filament fold C variant 2
 TATA-binding protein-associated factor 2N TATA-binding protein-associated factor 2N 0 1
TAF15 amyloid filament fold C variant 2
Homo sapiens Brain Prefrontal cortex TATA-binding protein-associated factor 2N Homo sapiens 0.061909
Amyloid filament formed by TAF15. Each chain is comprised of TAF15 residues 3-98.
4 LEVO MSDSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSQSGYSQSYGGYENQKQSSYSQ QPYNNQGQQQNMESSGSQGGRAPSYDQPDYGQQDSYDQQSGYDQHQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHT QDDRRDVSRYGEDNRGYGGSQGGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHRDYGPRTDADSESDNSDNNTIFVQG LGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATR RPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYG GERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYG GDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGG DRGGGYGGDRGGYGGKMGGRNDYRNDQRNRPY Q92804 helical filament 7.4 Quantifoil R1.2/1.3 GOLD 200 CARBON HOLEY GLOW DISCHARGE ETHANE FEI VITROBOT MARK IV TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 0.5 1.5 TFS FALCON 4i (4k x 4k) 1 36121 40.0 1 4.83 -1.48 C1 2.82 FSC 0.143 CUT-OFF RELION 5.0.1 2600 PHASE FLIPPING AND AMPLITUDE CORRECTION 136044 RELION 5.0.1
De novo initial model helix
 NOT APPLICABLE emd_56041.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 256 256 256 0 0 0 256 256 256 166.4 166.4 166.4 90.0 90.0 90.0 X Y Z -0.02269562 0.038869284 0.00020126079 0.0027642255 0.65 0.65 0.65 0.0115 AUTHOR TAF15 fold C variant 2 EM map emd_56041_msk_1.map emd_56041_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 256 256 256 0 0 0 256 256 256 166.4 166.4 166.4 90.0 90.0 90.0 X Y Z -0.068877965 0.074150555 0.0000651873 0.007753363 0.65 0.65 0.65 AUTHOR TAF15 fold C variant 2 EM half-map 2 emd_56041_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 256 256 256 0 0 0 256 256 256 166.4 166.4 166.4 90.0 90.0 90.0 X Y Z -0.0702001 0.07570612 0.00005902821 0.008362821 0.65 0.65 0.65 AUTHOR TAF15 fold C variant 2 EM half-map 1