2025-12-10 REL PDBj INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY PDBj PDBj 2024-12-07 2025-12-10 2025-12-10 2025-12-10 Not funded Structure of human B0AT1-ACE2 complex with compound1 Imazu T Miyaguchi I Hiraizumi M Inhibitor, amino acid transporter, SLC6, TRANSPORT PROTEIN Imazu T Akashi T Hiraizumi M Inui Y Sasaki W Takahashi T Todoroki H Kumanomidou T Hisano H Asada H Kusakizako T Nishizawa T Iwata S Nureki O Miyaguchi I Structure-guided development of a potent human B0AT1 inhibitor effective in a mouse model of phenylketonuria To Be Published 0353 9kxt FULLOVERLAP EMDB EMD-62627 associated EM volume
Structure of human B0AT1-ACE2 complex with compound1
 Ternary complex of B0AT1, ACE2 and inhibitor Ternary complex of B0AT1, ACE2 and inhibitor 0 1 2 Homo sapiens 0.16 Sodium-dependent neutral amino acid transporter B(0)AT1 Homo sapiens 0.073289359 1 Homo sapiens LEVO MADYKDDDDKSGPDEVDASGRVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPY LCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYL FNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTG KAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCE KDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVF QTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTG LICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPL LMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGDHQGLV STLSTASMNGDLKY Q695T7 Angiotensin-converting enzyme 2 Homo sapiens 0.092713898 1 Homo sapiens LEVO MRSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTL AQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYN ERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEH LHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVG LPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEG FHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWE MKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLR LGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNE MYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLND NSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNPGFQNTD DVQTSF Q9BYF1 3.4.17.23 3-(3-bromophenyl)-~{N}-ethyl-propanamide 0.000256139 1 A1L6U 2-acetamido-2-deoxy-beta-D-glucopyranose 0.000221208 1 NAG water 1.8015e-05 2 HOH singleParticle particle 7.5 ETHANE TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 0.8 1.6 GATAN K3 (6k x 4k) 7.6 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 6M18 2.7 FSC 0.143 CUT-OFF 125006 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_62627.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 288 288 288 0 0 0 288 288 288 318.72098 318.72098 318.72098 90.0 90.0 90.0 X Y Z -0.061929848 0.123683095 0.00003504969 0.0014930156 1.10667 1.10667 1.10667 0.0194 AUTHOR emd_62627_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 120 120 120 0 0 0 120 120 120 132.8004 132.8004 132.8004 90.0 90.0 90.0 X Y Z -0.024594633 0.058904905 0.0013820182 0.0040067784 1.10667 1.10667 1.10667 AUTHOR emd_62627_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 120 120 120 0 0 0 120 120 120 132.8004 132.8004 132.8004 90.0 90.0 90.0 X Y Z -0.022934642 0.054227114 0.0013828481 0.004033107 1.10667 1.10667 1.10667 AUTHOR