2025-11-05 REL PDBc INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY PDBj PDBc 2025-01-27 2025-11-05 2025-11-05 2025-11-05 National Natural Science Foundation of China (NSFC) China Structure of human DNMT3A-TCL1A complex Liu QT Li JH complex, TRANSFERASE Liu QT Li JH Molecular basis for inhibition of de novo DNA methylation by TCL1A To Be Published 0353 9lq1 FULLOVERLAP EMDB EMD-63290 associated EM volume
Structure of human DNMT3A-TCL1A complex
 Structure of human DNMT3A-TCL1A complex Structure of human DNMT3A-TCL1A complex 0 1 2 Homo sapiens Isoform 1 of DNA (cytosine-5)-methyltransferase 3A Homo sapiens 0.10199747699999999 2 Spodoptera frugiperda LEVO MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQ DSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIES MKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSR AAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVE VQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCV ECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLF DGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPG MNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNM SRLARQRLLGRSWSVPVIRHLFAPLKEYFACV Q9Y6K1 2.1.1.37 T-cell leukemia/lymphoma protein 1A Homo sapiens 0.013475537 4 Spodoptera frugiperda LEVO MAECPTLGEAVTDHPDRLWAWEKFVYLDEKQHAWLPLTIEIKDRLQLRVLLRREDVVLGRPMTPTQIGPSLLPIMWQLYP DGRYRSSDSSFWRLVYHIKIDGVEDMLLELLPDD P56279 ZINC ION 6.5409e-05 6 ZN singleParticle particle 2.0 8.0 150.0 NaCl sodium chloride 25.0 Tris Tris(hydroxymethyl)aminomethane 5.0 DTT Dithiothreitol
25mM Tris pH 8.0, 150mM NaCl,5 mM DTT
 Quantifoil R1.2/1.3 GOLD 300 CARBON ETHANE 100 277 FEI VITROBOT MARK IV
Vitrification carried out in argon atmosphere.
This sample was monodisperse
 TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 1.1 1.8 GATAN K2 SUMMIT (4k x 4k) 51.36 1 NONE 3.36 FSC 0.143 CUT-OFF Coot 0.9.8.1 2226401 ANGULAR RECONSTITUTION ANGULAR RECONSTITUTION emd_63290.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 330.0 330.0 330.0 90.0 90.0 90.0 X Y Z -1.564861 2.0969105 -0.0002915931 0.03242038 1.1 1.1 1.1 0.08 AUTHOR emd_63290_additional_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 330.0 330.0 330.0 90.0 90.0 90.0 X Y Z -0.9412055 1.5523902 -0.00022856609 0.023622971 1.1 1.1 1.1 AUTHOR emd_63290_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 330.0 330.0 330.0 90.0 90.0 90.0 X Y Z -0.4796182 0.9494244 0.00005862696 0.026390318 1.1 1.1 1.1 AUTHOR emd_63290_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 330.0 330.0 330.0 90.0 90.0 90.0 X Y Z -0.5034646 0.9511197 0.00006580632 0.02654039 1.1 1.1 1.1 AUTHOR