2025-11-26 REL PDBj INITIAL_RELEASE REPOSITORY PDBj PDBj 2025-04-22 2025-11-26 2025-11-26 2025-11-26 Science and Engineering Research Board (SERB) IPA/2020/000405 India Wellcome Trust IA/S/20/1/504916 United Kingdom Science and Engineering Research Board (SERB) CRG/2022/002646 India Structure of EP54 bound mouse C3aR in complex with Go Banerjee R Yadav MK Yadav R Ganguly M Mishra S Dalal A Gati C Shukla AK GPCR, G protein, SIGNALING PROTEIN, SIGNALING PROTEIN-IMMUNE SYSTEM complex Mishra S Yadav MK Dalal A Ganguly M Yadav R Sawada K Tiwari D Roy N Banerjee N Fung JN Marallag J Cui CS Li XX Lee JD Dsouza CA Saha S Sarma P Rawat G Zhu H Khant HA Clark RJ Sano FK Banerjee R Woodruff TM Nureki O Gati C Shukla AK Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors. Biorxiv US 2025 40501890 doi:10.1101/2025.05.26.656101 2692-8205 9umj FULLOVERLAP EMDB EMD-64276 associated EM volume
Structure of EP54 bound mouse C3aR in complex with Go
 EP54 bound to mouse C3aR in complex with Go EP54 bound to mouse C3aR in complex with Go 0 1 2 3 4 5 6 EP54 ligand 1 1 Guanine nucleotide-binding protein G(o) subunit alpha 1 3
This is a variant of Guanine nucleotide-binding protein G(o) subunit alpha called the "mini G(o) alpha"
Homo sapiens Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 4 Homo sapiens C3a anaphylatoxin chemotactic receptor, C3aR (mouse) 1 2 Mus musculus Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 1 5 Homo sapiens Antibody fragment 1 6 Mus musculus EP54 Ligand Homo sapiens 0.0012114749999999998 1 LEVO YSFKPMPL(DAL)R Muscarinic acetylcholine receptor M4,C3a anaphylatoxin chemotactic receptor Mus musculus 0.059526031 1 Spodoptera frugiperda LEVO MGKTIIALSYIFCLVFADYKDDDDAANFTPVNGSSGNQSVRLVTSSSLEVLFQGPGSESFDADTNSTDLHSRPLFQPQDI ASMVILGLTCLLGLLGNGLVLWVAGVKMKTTVNTVWFLHLTLADFLCCLSLPFSLAHLILQGHWPYGLFLCKLIPSIIIL NMFASVFLLTAISLDRCLIVHKPIWCQNHRNVRTAFAICGCVWVVAFVMCVPVFVYRDLFIMDNRSICRYNFDSSRSYDY WDYVYKLSLPESNSTDNSTAQLTGHMNDRSAPSSVQARDYFWTVTTALQSQPFLTSPEDSFSLDSANQQPHYGGKPPNVL TAAVPSGFPVEDRKSNTLNADAFLSAHTELFPTASSGHLYPYDFQGDYVDQFTYDNHVPTPLMAITITRLVVGFLVPFFI MVICYSLIVFRMRKTNFTKSRNKTFRVAVAVVTVFFICWTPYHLVGVLLLITDPESSLGEAVMSWDHMSIALASANSCFN PFLYALLGKDFRKKARQSIKGILEAAFSEELTHSTNCTQDKASSKRNNMSTDV P08173 O09047 Guanine nucleotide-binding protein G(o) subunit alpha Homo sapiens 0.027024761999999997 1 Escherichia coli LEVO MGHHHHHHENLYFQGTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGADNSGKSTIVKQMKIIHGGSGGSGGTTG IVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVDLSDYNRMHESLMLFDSICNNKFFIDTSIILFLNKKDL FGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNAQVIFDAVTDIIIANNLRGCGLY P09471 P09471 3.6.5.- Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Homo sapiens 0.038534061999999994 1 Spodoptera frugiperda LEVO MHHHHHHGSSGSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLL VSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR FLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDIN AICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAG HDNRVSCLGVTDDGMAVATGSWDSFLKIWN P62873 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Homo sapiens 0.007861143 1 Spodoptera frugiperda LEVO MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL P59768 Antibody fragment ScFv16 Mus musculus 0.026466486 1 Escherichia coli LEVO DVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAPEKGLEWVAYISSGSGTIYYADTVKGRFTISRDDPKNTLF LQMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTLTVSSGGGGSGGGGSGGGGSDIVMTQATSSVPVTPGESVSISCR SSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLEAEDVGVYYCMQHLEYPLTFG AGTKLELK singleParticle particle 7.4 ETHANE TFS GLACIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 200 0.8 3.2 FEI FALCON IV (4k x 4k) COUNTING 50.0 1 cryoSPARC 4.6.2 NONE 9KZ8 C1 3.38 FSC 0.143 CUT-OFF cryoSPARC 4.6.2 199691 MAXIMUM LIKELIHOOD cryoSPARC 4.6.2 MAXIMUM LIKELIHOOD cryoSPARC 4.6.2 cryoSPARC 4.6.2 emd_64276.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 216 216 216 0 0 0 216 216 216 327.0456 327.0456 327.0456 90.0 90.0 90.0 X Y Z -0.013190176 1.7455685 0.00068998866 0.017907828 1.5141 1.5141 1.5141 0.0844 AUTHOR FLEXIBLE FIT REAL emd_64276_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 216 216 216 0 0 0 216 216 216 327.0456 327.0456 327.0456 90.0 90.0 90.0 X Y Z -0.5880437 0.85366744 0.000030371513 0.036988415 1.5141 1.5141 1.5141 AUTHOR emd_64276_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 216 216 216 0 0 0 216 216 216 327.0456 327.0456 327.0456 90.0 90.0 90.0 X Y Z -0.5844621 0.9573139 0.00003253178 0.03719597 1.5141 1.5141 1.5141 AUTHOR