2025-11-19 REL PDBc INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY PDBj PDBc 2025-06-12 2025-11-19 2025-11-19 2025-11-19 National Science Foundation (NSF, China) China Structure of CVA6 empty capsid complexed with 3H7 Fab Ke X Li X Liu Z Liu K Yan X Shu B Zhang C coxsackievirus A6, KRM1, receptor, VIRUS Ke X Li X Liu Z Liu K Yan X Shu B Zhang C Structure of CVA6 empty capsid complexed with 3H7 Fab To Be Published 0353 9vg1 FULLOVERLAP EMDB EMD-65043 associated EM volume
Structure of CVA6 empty capsid complexed with 3H7 Fab
 purified CVA6 virus complexed with 3H7 Fab purified CVA6 virus complexed with 3H7 Fab 0 1 2 3 4 5
Purified Coxsackievirus A6 (CV-A6) virions were combined with KRM1 proteins at a 1:120 molar ratio (virus:protein) in PBS (pH 7.4). The binding reaction was carried out at room temperature for 35 minutes to allow complex formation. Immediately following incubation, samples were rapidly vitrified for cryo-EM analysis by plunge-freezing in liquid ethane.
Homo sapiens VL Mus musculus 0.011801075999999999 1 Mus musculus LEVO DIQMTQSPSSLSASLGERVSLTCRASQDIGSRLNWLQQEPDGTIKRLIYATSSLDSGVPKRFSGSRSGSYYSLTISSLES EDFVDYYCLQYAGFPWTFGGGTKLEIK VH Mus musculus 0.013671103999999998 1 Mus musculus LEVO EVKLVESGGGLVKPGGSLKLSCAASGFAFSTYDMSWVRQTPEKRLEWVATISSGGSYTYYPDSVKGRFTISRDNARNTLY LQMSSLRSEDTALYYCARGGPYDYDGSFYTMDYWGQGTSVTVSS Genome polyprotein Coxsackievirus A6 0.033568379
THE FIRST AMINO-ACID OF VP1 IN THE CORRESPONDING SECTION OF THE GENBANK POLYPROTEIN ENTRY (AAR38844) (ASN) IS NOT THE ACTUAL FIRST RESIDUE AS THE PROTEOLYTIC CLEAVAGE OF THE VIRAL POLYPROTEIN OCCURS AT AN ALTERNATIVE LOCATION, LEAVING THE FOLLOWING RESIDUE ASP-2 AS THE FIRST RESIDUE (D-1), AND THE ASN AS THE EXTRA C-TERM RESIDUE DESCRIBED FOR VP3 (N-241) AS IT WAS OBSERVED IN THE VIRION.
1 LEVO NDPITNAVESAVSALADTTISRVTAANTAASTHSLGTGRVPALQAAETGASSNSSDENLIETRCVMNRNGVNEASVEHFY SRAGLVGVVEVKDSGTSLDGYTVWPIDVMGFVQQRRKLELSTYMRFDAEFTFVSNLNNSTTPGMLLQYMYVPPGAPKPDS RKSYQWQTATNPSVFAKLSDPPPQVSVPFMSPATAYQWFYDGYPTFGEHKQATNLQYGQCPNNMMGHFAIRTVSESTTGK NIHVRVYMRIKHVRAWVPRPLRSQAYMVKNYPTYSQTITNTATDRASITTTDYEGGVPASPQRTS A0A222NWY2 Genome polyprotein Coxsackievirus A6 0.026324759999999996 1 LEVO GFPTELKPGTNQFLTTDDGTSPPILPGFEPTPLIHIPGEFTSLLDLCQVETILEVNNTTGTTGVSRLLIPVRAQNNVDQL CASFQVDPGRNGPWQSTMVGQICRYYTQWSGSLKVTFMFTGSFMATGKMLIAYTPPGSAQPTTREAAMLGTHIVWDFGLQ SSVTLVIPWISNTHFRAVKTGGVYDYYATGIVTIWYQTNFVVPPDTPTEANIIALGAAQKNFTLKLCKDTDEIQQTAEYQ A0A4P2SK07 3.4.22.29 Genome polyprotein Coxsackievirus A6 0.028138603999999998 1 LEVO SPSVEACGYSDRVAQLTVGNSTITTQEAANIVLSYGEWPEYCPSTDATAVDKPTRPDVSVNRFYTLSTKSWKTESTGWYW KFPDVLNDTGVFGQNAQFHYLYRSGFCMHVQCNASKFHQGALLVAAIPEFVIAASSPATKPNSQGLYPDFAHTNPGKDGQ EFRDPYVLDAGIPLSQALIFPHQWINLRTNNCATIIMPYINALPFDSALNHSNFGLVVIPISPLKYCNGATTEVPITLTI APLNSEFSGLRQAIKQ A0A7D0TR32 3.4.22.29 singleParticle particle 3.12 7.4 EMS Lacey Carbon COPPER 400 CARBON LACEY ETHANE 100 273.0 FEI VITROBOT MARK IV JEOL CRYO ARM 300 FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 2.7 0.5 2.5 JEOL CRYOSPECPORTER NITROGEN GATAN K3 BIOQUANTUM (6k x 4k) 1 8563 2.7 40.0 1 202528 PHASE FLIPPING AND AMPLITUDE CORRECTION AB-initio reconstructuction in cryoSPARC (V4.5.3) I FOURIER SPACE 3.26 FSC 0.143 CUT-OFF cryoSPARC 810 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_65043.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 600 600 600 0 0 0 600 600 600 570.0 570.0 570.0 90.0 90.0 90.0 X Y Z -0.29203194 0.6068567 0.00256944 0.037756354 0.95 0.95 0.95 0.09 AUTHOR AB INITIO MODEL REAL emd_65043_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 600 600 600 0 0 0 600 600 600 570.0 570.0 570.0 90.0 90.0 90.0 X Y Z -2.419194 2.1044626 0.0014760349 0.20609497 0.95 0.95 0.95 AUTHOR emd_65043_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 600 600 600 0 0 0 600 600 600 570.0 570.0 570.0 90.0 90.0 90.0 X Y Z -1.9813621 1.5256544 0.0014855707 0.20466837 0.95 0.95 0.95 AUTHOR