2026-04-01 REL PDBc INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY DATABASE_REFERENCES citation citation_author em_admin _citation.journal_id_ISSN _citation.journal_volume _citation.page_first _citation.page_last _citation.pdbx_database_id_DOI _citation.pdbx_database_id_PubMed _citation.title _em_admin.last_update EXPERIMENTAL_SUMMARY citation citation_author em_admin _citation.journal_id_ISSN _citation.journal_volume _citation.page_first _citation.page_last _citation.pdbx_database_id_DOI _citation.pdbx_database_id_PubMed _citation.title _em_admin.last_update PDBj PDBc 2025-06-19 2025-11-12 2025-11-12 2026-04-01 National Natural Science Foundation of China (NSFC) GG9100007022 China Cryo-EM structure of 5-HT1AR-GoA in complex with gepirone Wang C Cao C signal transduction, MEMBRANE PROTEIN Wang C Zhang N Shao Y Li T Zhang M Gao M Liang Y Wang Y Xue T Shi Y Chen H Cao C Pathway-selective 5-HT 1A R agonist as a rapid antidepressant strategy. Cell 188 7222 7237.e24 2025 41232528 doi:10.1016/j.cell.2025.10.022 1097-4172 9vj5 FULLOVERLAP EMDB EMD-65104 associated EM volume
Structure of a membrane protein with compound-1
 Cryo-EM structure of 5-HT1AR-GoA in complex with gepirone Cryo-EM structure of 5-HT1AR-GoA in complex with gepirone 0 1 2 3 4 5 Homo sapiens 0.15 Guanine nucleotide-binding protein G(o) subunit alpha Homo sapiens 0.040081438 1 Spodoptera frugiperda LEVO MGSTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKNTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQS LAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSL DRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGAQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDET TNRMHASLKLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIY CHMTCSTDTNNIQVVFDAVTDIIIANNLRGCGLY P09471 3.6.5.- Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Homo sapiens 0.039418086 1 Spodoptera frugiperda LEVO MHHHHHHLEVLFQGPGSSGSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMH WGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGH TGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKA DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN P62873 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Homo sapiens 0.007861143 1 Spodoptera frugiperda LEVO MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL P59768 scFv16 Mus musculus 0.026679721 1 Spodoptera frugiperda LEVO DVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAPEKGLEWVAYISSGSGTIYYADTVKGRFTISRDDPKNTLF LQMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTLTVSSGGGGSGGGGSGGGGSDIVMTQATSSVPVTPGESVSISCR SSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLEAEDVGVYYCMQHLEYPLTFG AGTKLELKAAA Soluble cytochrome b562,5-hydroxytryptamine receptor 1A Homo sapiens 0.060921188 1 Spodoptera frugiperda LEVO DYKDDDDAKLQTMHHHHHHHHHHENLYFQGGTTMADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPP KLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLGSTLEVLFQGPTTGISDVTV SYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFI ALDVLCCTSSIWHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDH GYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGG ALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGT FILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ P0ABE7 P08908 Gepirone 0.000359466 1 A1ESA CHOLESTEROL 0.000386654 2 CLR (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate 0.0009530809999999999 1 T7M singleParticle particle 1.5 7.5 Quantifoil R1.2/1.3 COPPER 300 CARBON HOLEY ETHANE 100 277 FEI VITROBOT MARK IV TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 0.6 18.0 GATAN K3 (6k x 4k) 50.0 1 1618632 NONE 7E2Z 2.69 FSC 0.143 CUT-OFF cryoSPARC v4.41 180175 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD cryoSPARC v4.4.1 emd_65104.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 356 356 356 0 0 0 356 356 356 291.91998 291.91998 291.91998 90.0 90.0 90.0 X Y Z -2.6047814 4.3303814 -0.0010304728 0.070935704 0.81999993 0.81999993 0.81999993 0.5 AUTHOR emd_65104_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 356 356 356 0 0 0 356 356 356 291.91998 291.91998 291.91998 90.0 90.0 90.0 X Y Z -0.98415834 1.619977 0.00014087325 0.07057001 0.81999993 0.81999993 0.81999993 AUTHOR emd_65104_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 356 356 356 0 0 0 356 356 356 291.91998 291.91998 291.91998 90.0 90.0 90.0 X Y Z -0.98273885 1.5965405 0.00013329752 0.070486404 0.81999993 0.81999993 0.81999993 AUTHOR