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            <date>2026-03-25</date>
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            <deposition>PDBj</deposition>
            <last_processing>PDBc</last_processing>
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            <deposition>2025-07-15</deposition>
            <header_release>2026-03-25</header_release>
            <map_release>2026-03-25</map_release>
            <update>2026-03-25</update>
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                <funding_body>National Natural Science Foundation of China (NSFC)</funding_body>
                <code>92354306</code>
                <country>China</country>
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        </grant_support>
        <title>Cryo-EM structure of the erlin1/2 complex purified using DDM and GDN</title>
        <authors_list>
            <author>Yan L</author>
            <author>Gao N</author>
        </authors_list>
        <keywords>Cryo-EM, complex, MEMBRANE PROTEIN, SPFH protein family</keywords>
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        <citation_list>
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                <journal_citation published="true">
                    <author ORCID="0000-0003-2858-395X" order="1">Yan L</author>
                    <author ORCID="0000-0003-3067-9993" order="2">Gao N</author>
                    <title>The Erlin1/2 complex is a dynamic scaffold for membrane microdomain assembly on the endoplasmic reticulum</title>
                    <journal_abbreviation>Mol.Cell</journal_abbreviation>
                    <country>US</country>
                    <year>2026</year>
                    <external_references type="ISSN">1097-2765</external_references>
                    <external_references type="CSD">2168</external_references>
                    <external_references type="ASTM">MOCEFL</external_references>
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                <details>Cryo-EM structure of the cage-top domain of the erlin1/2 complex purified using DDM and GDN</details>
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                <emdb_id>EMD-65432</emdb_id>
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                <details>Cryo-EM overall structure of the erlin1/2 complex purified using DDM and GDN</details>
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                <details>Cryo-EM overall structure of the erlin1/2 complex purified using DDM and GDN</details>
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        <name>The erlin1/2 complex</name>
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            <complex_supramolecule supramolecule_id="1">
                <name>The erlin1/2 complex</name>
                <parent>0</parent>
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                    <macromolecule>
                        <macromolecule_id>2</macromolecule_id>
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                    <organism ncbi="9606">Homo sapiens</organism>
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                    <organism ncbi="9606">Homo sapiens</organism>
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                <number_of_copies>13</number_of_copies>
                <recombinant_expression database="NCBI">
                    <recombinant_organism ncbi="9606">Homo sapiens</recombinant_organism>
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                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>ARVLVAAVVGLVAVLLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVM
IYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNLMAPGL
TIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKKAVIEAEKIAQVAKIRFQQKVMEKETEKRIS
EIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVD</string>
                    <external_references type="UNIPROTKB">O75477</external_references>
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            <protein_or_peptide macromolecule_id="2">
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                <enantiomer>LEVO</enantiomer>
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VIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKIS
EIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKMYFGKDIPNMFMD</string>
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