2026-01-28 REL PDBc INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY EXPERIMENTAL_SUMMARY citation em_admin _citation.journal_volume _citation.page_first _citation.year _em_admin.last_update DATABASE_REFERENCES citation em_admin _citation.journal_volume _citation.page_first _citation.year _em_admin.last_update PDBj PDBc 2025-08-31 2025-11-05 2025-11-05 2026-01-28 National Natural Science Foundation of China (NSFC) 32471252 China Alkylsulfone-bound human VAChT Zhang Z Zhang Y VAChT, SLC18A3, Acetylcholine, Alkylsulfone, TRANSPORT PROTEIN Zhang Y Zhang Z Structural basis of VAChT inhibition by spiroindolines and alkylsulfones. Structure UK 34 123 2026 41172986 doi:10.1016/j.str.2025.10.005 0969-2126 2005 STRUE6 9wji FULLOVERLAP EMDB EMD-66019 associated EM volume
Alkylsulfone-bound human VAChT
 human VAChT in complex with alkylsulfone human VAChT in complex with alkylsulfone 0 1 Homo sapiens 0.1 Maltose/maltodextrin-binding periplasmic protein,Vesicular acetylcholine transporter,DARPins synthetic construct 0.11270517999999999 1 Homo sapiens LEVO MEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITP DKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLI AADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLIDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVN YGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELVKDPRVAATM ENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALAAAQAEEEKRKAEEEKRKLVLVIVCVALLLDNMLYMVIVP IVPDYIAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESEDVKIGVLFASKAILQ LLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALG VALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVA GALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGASSCIVP ACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGM GLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDECEDDGGGGSGGGGSD LGRKLLEAARAGQLDEVRILLANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFGYTPLHLAAYWGHL EIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGADVNAQDKFGKTAFDISIDNGNEDLAEILQKLNLEGG SLEVLFQ P0AEX9 Q16572 2-(3-ethylsulfonylpyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine 0.00037035000000000003 1 A1EWW singleParticle particle 8 7.25 ETHANE FEI POLARA 300 FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 1.5 2.0 GATAN K3 (6k x 4k) 60.0 1 NONE 3.4 FSC 0.143 CUT-OFF cryoSPARC 210095 ANGULAR RECONSTITUTION ANGULAR RECONSTITUTION emd_66019.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 320 320 320 0 0 0 320 320 320 265.6 265.6 265.6 90.0 90.0 90.0 X Y Z -3.2390983 4.1193056 0.00042033664 0.03683148 0.83000004 0.83000004 0.83000004 0.15 AUTHOR emd_66019_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 320 320 320 0 0 0 320 320 320 265.6 265.6 265.6 90.0 90.0 90.0 X Y Z -0.6106655 1.0893706 0.000625681 0.038927574 0.83000004 0.83000004 0.83000004 AUTHOR emd_66019_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 320 320 320 0 0 0 320 320 320 265.6 265.6 265.6 90.0 90.0 90.0 X Y Z -0.6118922 0.97263175 0.0006266598 0.038982127 0.83000004 0.83000004 0.83000004 AUTHOR