2026-07-08 REL PDBc INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY PDBj PDBc 2025-10-27 2026-07-08 2026-07-08 2026-07-08 National Natural Science Foundation of China (NSFC) 32371288 China National Natural Science Foundation of China (NSFC) 323B2038 China Cryo-EM structure of asimadoline-BMS-986187-bound KOR-Gi1 complex Zhao C Fu H Tian XW Cheng L Shao ZH Complex, Agonist, MEMBRANE PROTEIN Wang H Miao Z Zhao C Fu H Tian X Liu X Wang L Liu Y Liu X Yong X Su L Yan W Cheng L Chai R Shao Z Ke B Molecular mechanism of allosteric modulation of opioid receptors. Signal Transduct Target Ther UK 11 2026 42362532 doi:10.1038/s41392-026-02759-5 2059-3635 EMD-66830 consensus EM volume EMD-66828 focused EM volume EMD-66829 focused EM volume 9xdr FULLOVERLAP EMDB EMD-66773 associated EM volume
Cryo-EM structure of asimadoline-BMS-986187-bound KOR-Gi1 complex
 EMDB EMD-66830 consensus EM volume EMDB EMD-66828 focused EM volume EMDB EMD-66829 focused EM volume MOR in complex with Gi heterotrimer MOR in complex with Gi heterotrimer 0 1 2 3 4 Homo sapiens Guanine nucleotide-binding protein G(i) subunit alpha-1 Oplophorus gracilirostris 0.040414046999999995 1 Spodoptera frugiperda LEVO MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKNTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQS IIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLD RIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGAQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM NRMHASMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIY THFTCSTDTKNVQFVFDAVTDVIIKNNLKDCGLF P63097 3.6.5.- Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Homo sapiens 0.041729582 1 Spodoptera frugiperda LEVO MHHHHHHLEVLFQGPGSSGSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMH WGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGH TGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKA DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWNGGSGGGGSGGSSSGGVSGWRLFKKIS P62873 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Homo sapiens 0.007861143 1 Spodoptera frugiperda LEVO MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL P59768 Soluble cytochrome b562,Kappa-type opioid receptor,Soluble cytochrome b562,Kappa-type opioid receptor,Oplophorus-luciferin 2-monooxygenase catalytic subunit synthetic construct 0.06779348399999999 1 Spodoptera frugiperda LEVO MKTIIALSYIFCLVFADYKDDDDAADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSP EMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLISPAIPVIITAVYSVVFVVGLVGNSLVMFV IIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHP VKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIII VCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNS SLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSGGSGGGGSGGSSSGGVFTLEDFVGDWEQTAAYNLDQVLEQGGVSS LLQNLAVSVTPIQRIVRSGENALKIDIHVIIPYEGLSADQMAQIEEVFKVVYPVDDHHFKVILPYGTLVIDGVTPNMLNY FGRPYEGIAVFDGKKITVTGTLWNGNKIIDERLITPDGSMLFRVTINS P0ABE7 P41145 Asimadoline 0.00041453899999999996 1 A1E0F 3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-4,5,7,9-tetrahydro-2~{H}-xanthene-1,8-dione 0.000470599 1 A1D6B singleParticle particle 7.5 ETHANE TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 2.7 0.8 1.4000000000000001 FEI FALCON IV (4k x 4k) 50.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 2.58 FSC 0.143 CUT-OFF cryoSPARC 352862 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_66773.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 228.0 228.0 228.0 90.0 90.0 90.0 X Y Z -0.3772978 1.3177114 0.005232174 0.024679689 0.76 0.76 0.76 0.15 AUTHOR