2026-02-04 REL PDBc INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY PDBj PDBc 2025-11-18 2026-02-04 2026-02-04 2026-02-04 National Fund for Scientific Research Belgium A composite Cryo-EM structure of GPR75 Yuan Q Wu C GPCR, GPR75, MEMBRANE PROTEIN/IMMUNE SYSTEM, MEMBRANE PROTEIN-IMMUNE SYSTEM complex Zhu ZN You CZ Yuan QN Xu JY Gu ZY Huang Z Liu M Shan B Wang JJ Hu W Wang K Yin WC Xu YW Xu HE Wu CR Cryo-EM structures of GPR75 reveal an occluded orthosteric pocket challenging conventional drug discovery paradigms for an anti-obesity target. Acta Pharmacol.Sin. CN 2026 41545757 doi:10.1038/s41401-025-01720-6 1745-7254 EMD-67109 consensus EM volume
consensus map of GPR75
 EMD-67108 focused EM volume
focused map of Receptor of GPR75
 9xqc FULLOVERLAP EMDB EMD-67109 consensus EM volume
consensus map of GPR75
 EMDB EMD-67108 focused EM volume
focused map of Receptor of GPR75
 EMDB EMD-67110 associated EM volume
A composite Cryo-EM structure of GPR75
 A composite Cryo-EM structure of GPR75 A composite Cryo-EM structure of GPR75 0 1 2 3 4 5 Homo sapiens G subunit alpha (q) Homo sapiens 0.041724383 1 Spodoptera frugiperda LEVO MGCTLSAEDKAAVERSKMIEKQLQKDKQVYRRTLRLLLLGADNSGKSTIVKQMRIYHVNGYSEEECKQYKAVVYSNTIQS IIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLD RIAQPNYIPTQQDVLRTRVKTSGIFETKFQVDKVNFHMFDVGAQRDERRKWIQCFNDVTAIIFVVDSSDYNRLQEALNDF KSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRKEFVDISTASG DGRHICYPHFTCSVDTENARRIFNDCKDIILQMNLREYNLV Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Homo sapiens 0.03777136699999999 1 Spodoptera frugiperda LEVO MLLQSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDG KLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQI VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPN GNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSC LGVTDDGMAVATGSWDSFLKIWN P62873 Antibody fragment scFv16 Mus musculus 0.026277298999999997 1 Spodoptera frugiperda LEVO VQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAPEKGLEWVAYISSGSGTIYYADTVKGRFTISRDDPKNTLFL QMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTLTVSAGGGGSGGGGSGGGGSADIVMTQATSSVPVTPGESVSISCR SSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLEAEDVGVYYCMQHLEYPLTFG AGTKLEL Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Homo sapiens 0.007861143 1 Spodoptera frugiperda LEVO MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL P59768 Probable G-protein coupled receptor 75,Maltose/maltodextrin-binding periplasmic protein Escherichia coli K-12 0.048262516 1 Spodoptera frugiperda LEVO DLIHTATLVTCTFLLAVIFCLGSYGNFIVFLSFFDPAFRKFRTNFDFMILNLSFCDLFICGVTAPMFTFVLFFSSASSIP DAFCFTFHLTSSGFIIMSLKTVAVIALHRLRMVLGKQPNRTASFPCTVLLTLLLWATSFTLATLATLKTSKSHLCLPMSS LIAGKGKAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVRKCPPVITVDASRPQPFMGVPVQGGGDPIQCAMPALYRN QNYNKLQHVQTRGYTKSPNQLVTPAASRLQLVSAINLSTAKDSKAVVTCVIIVLSVLVCCLPLGISLVQVVLSSNGSFIL YQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLQLEGSAGSAAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGI KVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQS O95800 P0AEX9 water 1.8015e-05 6 HOH singleParticle particle 7.4 ETHANE TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 8.0 18.0 FEI FALCON IV (4k x 4k) 50.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 3.0 FSC 0.143 CUT-OFF cryoSPARC 165428 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_67110.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 320 320 320 0 0 0 320 320 320 263.68 263.68 263.68 90.0 90.0 90.0 X Y Z -3.1102593 5.611493 -0.0029552574 0.08736347 0.824 0.824 0.824 0.6 AUTHOR