2026-04-01 REL PDBc INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY DATABASE_REFERENCES citation citation_author em_admin _citation.journal_volume _citation_author.identifier_ORCID _em_admin.last_update EXPERIMENTAL_SUMMARY citation citation_author em_admin _citation.journal_volume _citation_author.identifier_ORCID _em_admin.last_update PDBj PDBc 2025-11-19 2026-03-18 2026-03-18 2026-04-01 Ministry of Science and Technology (MoST, China) 2022YFA1303500 China LolCDE in complex with SMT-738_3 Dong CJ Li HT Bacterial lipoprotein transporter, LolCDE inhibitor, Cryo-EM, Allosteric conformational change, TRANSPORT PROTEIN Li H Zhu X Zhang D Duan X Li J Qu Y Li D Zhang Z Dong H Guo FB Dong C Molecular mechanism of action of small molecule SMT-738 on bacterial lipoprotein transporter LolCDE. Nat Commun UK 17 2026 41663437 doi:10.1038/s41467-026-69411-2 2041-1723 EMD-67112 consensus EM volume
LolCDE in complex with SMT-738_1
 EMD-67113 focused EM volume
LolCDE in complex with SMT-738_2
 9xro FULLOVERLAP EMDB EMD-67112 consensus EM volume
LolCDE in complex with SMT-738_1
 EMDB EMD-67113 focused EM volume
LolCDE in complex with SMT-738_2
 EMDB EMD-67153 associated EM volume
LolCDE in complex with SMT-738_3
 LolCDE in complex with SMT-738_3 LolCDE in complex with SMT-738_3 0 1 2 3
an inhibitor SMT-738 bound LolCDE
Escherichia coli MG1655 0.115 Lipoprotein-releasing system transmembrane protein LolC Escherichia coli K-12 0.043295516 1 Escherichia coli BL21(DE3) LEVO MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSSEHGSLNPQQL PETAVKLDGVNRVAPITTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQTDLEPGKYNVILGEQLASQLGVNRGD QIRVMVPSASQFTPMGRIPSQRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKL PEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGAS AGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAIEPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE P0ADC3 Lipoprotein-releasing system transmembrane protein LolE Escherichia coli K-12 0.045385976999999994 1 Escherichia coli BL21(DE3) LEVO MAMPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRILAVVPHGEIEAVDQPWTNWQE ALDHVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVNPQQEQRLSALPSFVQGDAWRNFKAGEQQIIIGKGVADALKV KQGDWVSIMIPNSNPEHKLMQPKRVRLHVAGILQLSGQLDHSFAMIPLADAQQYLDMGSSVSGIALKMTDVFNANKLVRD AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMVLVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGLIRAIFV WYGLLAGLFGSLCGVIIGVVVSLQLTPIIEWIEKLIGHQFLSSDIYFIDFLPSELHWLDVFYVLVTALLLSLLASWYPAR RASNIDPARVLSGQ P75958 Lipoprotein-releasing system ATP-binding protein LolD Escherichia coli K-12 0.026576465 1 Escherichia coli BL21(DE3) LEVO MNKILLQCDNLCKRYQEGSVQTDVLHNVSFSVGEGEMMAIVGSSGSGKSTLLHLLGGLDTPTSGDVIFNGQPMSKLSSAA KAELRNQKLGFIYQFHHLLPDFTALENVAMPLLIGKKKPAEINSRALEMLKAVGLDHRANHRPSELSGGERQRVAIARAL VNNPRLVLADEPTGNLDARNADSIFQLLGELNRLQGTAFLVVTHDLQLAKRMSRQLEMRDGRLTAELSLMGAEHHHHHHH H P75957 7.6.2.- 2-azanyl-1-[6-[2-azanyl-5-(3-methylpyridin-4-yl)-1H-imidazol-4-yl]-2,3-dihydro-1,4-benzoxazin-4-yl]-2-methyl-propan-1-one 0.000392454 1 A1ER4 singleParticle particle 1.0 7.8 0.15 NaCl sodium chloride 0.02 Tris 2-Amino-2- (hydroxymethyl)-1,3-propanediol Quantifoil R1.2/1.3 COPPER 300 CARBON CONTINUOUS GLOW DISCHARGE ETHANE
This sample was monodisperse.
 TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 0.8 2.5 GATAN K3 (6k x 4k) 50.0 1 cryoSPARC v4.1 PHASE FLIPPING AND AMPLITUDE CORRECTION 2.88 OTHER cryoSPARC v4.1 403023 PROJECTION MATCHING PROJECTION MATCHING emd_67153.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 360 360 360 0 0 0 360 360 360 296.64 296.64 296.64 90.0 90.0 90.0 X Y Z -1.1288238 2.113032 0.0057630227 0.029977938 0.82400006 0.82400006 0.82400006 0.108 AUTHOR LolCDE-SMT-738_composition map_image