2025-10-01 REL RCSB INITIAL_RELEASE REPOSITORY RCSB RCSB 2025-04-04 2025-10-01 2025-10-01 2025-10-01 Bill & Melinda Gates Foundation INV-002143 United States BG505 SOSIP in complex with 007 bNAb IgG1 - trimer-dimer class DeLaitsch AT Bjorkman PJ antibody, envelope, SOSIP, VIRAL PROTEIN-IMMUNE SYSTEM complex Gieselmann L DeLaitsch AT Rohde M Radford C Worczinski J Momot A Ahmadov E Burger JA Havenar-Daughton C Deshpande S Giovannoni F Corti D Kreer C Ercanoglu MS Schommers P Georgiev IS West AP Knufer J Stumpf R Kroidl A Geldmacher C Maganga L William W Ntinginya NE Hoelscher M Yang Z Wei Q Renfrow M Green TJ Novak J van Gils MJ Gristick HB Gruell H Bloom JD Seaman MS Bjorkman PJ Klein F Identification of a broad and potent V3 glycan site bNAb targeting an N332 gp120 glycan-independent epitope. Biorxiv US 2025 40964353 doi:10.1101/2025.09.05.674437 2692-8205 9o2u FULLOVERLAP EMDB EMD-70022 associated EM volume
BG505 SOSIP in complex with 007 bNAb IgG1 - trimer-dimer class
 HIV-1 BG505 SOSIP trimer bound by three 007 bNAb IgG1 molecules HIV-1 BG505 SOSIP trimer bound by three 007 bNAb IgG1 molecules 0 1 2 3 4 Homo sapiens Envelope glycoprotein gp120 Human immunodeficiency virus 1 0.053392499999999996 6 Homo sapiens LEVO NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLW DQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYR LINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMI RSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHF GNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAM YAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRR Q2N0S6 Envelope glycoprotein gp41 Human immunodeficiency virus 1 0.017618064 6 Homo sapiens LEVO RRRAVGIGAVFLGFLGAAGSTMGAASMTLTVQARNLLSGIVQQQSNLLRAPEAQQHLLKLTVWGIKQLQARVLAVERYLR DQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD Q2N0S6 007 IgG1 Heavy Chain Homo sapiens 0.050497046999999996 6 Homo sapiens LEVO QARLQQWEGRPLKPAETLSLTCGVHGVGLGGSGWGWIRQPPGQGLQWIGEIDHDGSHKHNPALRSRLSMSLDTSRNQVSL RLTSVTAADTAIYYCVRVYREKFLIGEFLTDYRFMDMWGTGTTVIVSPASTKGPSVFPLAPSSKSTSGGTAALGCLVKDY FPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPC PAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVL HQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 007 Light Chain Homo sapiens 0.02350027 6 Homo sapiens LEVO AIQLTQAPLTVSASIGDTITLTCRASQDISIWLSWYRQMPGKAPELLIYAASTLRGGVPSRFSGARSGTDFSLKIKNLQP EDFATYYCFQSDSYPRAFGQGTKVEITRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 2-acetamido-2-deoxy-beta-D-glucopyranose 0.000221208 48 NAG singleParticle particle 2.6 8.0 20.0 Tris 150.0 NaCl Sodium Chloride Quantifoil R1.2/1.3 COPPER 300 CARBON GLOW DISCHARGE ETHANE 100 295 FEI VITROBOT MARK IV FEI TALOS ARCTICA FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 200 1.0 3.0 GATAN K3 (6k x 4k) 1 2290 45.0 1 cryoSPARC PHASE FLIPPING AND AMPLITUDE CORRECTION Ab initio model generated in cryoSPARC D3 4.2 FSC 0.143 CUT-OFF cryoSPARC 49254 MAXIMUM LIKELIHOOD cryoSPARC MAXIMUM LIKELIHOOD cryoSPARC emd_70022.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 360 360 360 0 0 0 360 360 360 518.4 518.4 518.4 90.0 90.0 90.0 X Y Z -0.552949 1.1524975 0.0007661096 0.026422873 1.44 1.44 1.44 0.18 AUTHOR Sharpened EM map 6UDJ PDB experimental model 5BZD PDB experimental model 7PS3 PDB experimental model 8UKI PDB experimental model RIGID BODY FIT
chains individually rigid body fit into density
 emd_70022_additional_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 360 360 360 0 0 0 360 360 360 518.4 518.4 518.4 90.0 90.0 90.0 X Y Z -0.105654635 0.49889278 0.0007661096 0.019333264 1.44 1.44 1.44 AUTHOR Unsharpened EM map emd_70022_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 360 360 360 0 0 0 360 360 360 518.4 518.4 518.4 90.0 90.0 90.0 X Y Z -0.14409846 0.55194944 0.0009716914 0.023799166 1.44 1.44 1.44 AUTHOR EM half map A emd_70022_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 360 360 360 0 0 0 360 360 360 518.4 518.4 518.4 90.0 90.0 90.0 X Y Z -0.15387554 0.5697174 0.0009766608 0.023800606 1.44 1.44 1.44 AUTHOR EM half map B