2025-08-13 REL RCSB INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY DATABASE_REFERENCES citation citation_author em_admin _citation.country _citation.journal_abbrev _citation.journal_id_ASTM _citation.journal_id_CSD _citation.journal_id_ISSN _citation.journal_volume _citation.page_first _citation.page_last _citation.pdbx_database_id_DOI _citation.pdbx_database_id_PubMed _citation.title _citation.year _citation_author.identifier_ORCID _citation_author.name _em_admin.last_update RCSB RCSB 2025-04-09 2025-07-23 2025-07-23 2025-08-13 National Institutes of Health/National Cancer Institute (NIH/NCI) United States Structure of a synthetic antibody (RM010) in complex with a class I MHC presenting a hapten-peptide conjugate Hu Z Rajak E Maso L Koide S Complex, Fab, IMMUNE SYSTEM Maso L Rajak E Hattori T Hu Z Koide A Neel BG Koide S Generation of actionable, cancer-specific neoantigens from KRAS(G12C) with adagrasib. Proc.Natl.Acad.Sci.USA US 122 e2509012122 e2509012122 2025 40737322 doi:10.1073/pnas.2509012122 1091-6490 0040 PNASA6 9o55 FULLOVERLAP EMDB EMD-70124 associated EM volume
Structure of a synthetic antibody (RM010) in complex with a class I MHC presenting a hapten-peptide conjugate
 Binary complex of Fab RM010 with adagrasib-conjugated KRAS G12C peptide presented by HLA-A11 Binary complex of Fab RM010 with adagrasib-conjugated KRAS G12C peptide presented by HLA-A11 0 1 4 3 Homo sapiens MHC class I antigen Homo sapiens 0.021081148 1 Escherichia coli LEVO GSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGT LRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHAAEQQRAYL EGRCVEWLRRYLENGKETLQR A0A6B7HGG7 GTPase KRas, N-terminally processed Homo sapiens 0.000889094 1 Escherichia coli LEVO VVVGACGVGK P01116 RM010 Fab heavy chain Homo sapiens 0.012432711999999999 1 Escherichia coli LEVO EVQLVESGGGLVQPGGSLRLSCAASGFTFSSSSIHWVRQAPGKGLEWVASISSSSGSTSYADSVKGRFTISADTSKNTAY LQMNSLRAEDTAVYYCARFQWYAMDYWGQGTLVTVS RM010 Fab light chain Homo sapiens 0.011914289 1 Escherichia coli LEVO DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQP EDFATYYCQQSSWLYWLVTFGQGTKVEIK [(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile 0.000606133 1 A1B8E singleParticle particle 7.4 ETHANE TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 0.5 2.5 GATAN K3 (6k x 4k) 47.31 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 8VR9 2.88 FSC 0.143 CUT-OFF 155365 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_70124.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 340 340 340 0 0 0 340 340 340 280.5 280.5 280.5 90.0 90.0 90.0 X Y Z -3.01757 4.4128876 0.0012807809 0.072720535 0.825 0.825 0.825 0.85 AUTHOR 106.400000000000006 emd_70124_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 340 340 340 0 0 0 340 340 340 280.5 280.5 280.5 90.0 90.0 90.0 X Y Z -0.5713608 1.3250525 0.0010453725 0.06670978 0.825 0.825 0.825 AUTHOR emd_70124_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 340 340 340 0 0 0 340 340 340 280.5 280.5 280.5 90.0 90.0 90.0 X Y Z -0.5722079 1.3125213 0.0010556778 0.06654655 0.825 0.825 0.825 AUTHOR