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                <country>United States</country>
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        <title>Cryo-EM structure of NI06063_d30_103 Fab in complex with influenza virus hemagglutinin from A/Hong Kong/485197/2014 (H3N2)</title>
        <authors_list>
            <author>Jo G</author>
            <author>Ward AB</author>
        </authors_list>
        <keywords>Influenza, Hemagglutinin, Antibody complex, Viral protein, Viral protein-Immune System complex</keywords>
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        <citation_list>
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                <journal_citation published="true">
                    <author order="1">Sun J</author>
                    <author ORCID="0000-0001-7221-2561" order="2">Jo G</author>
                    <author ORCID="0009-0003-9647-324X" order="3">Troxell CA</author>
                    <author order="4">Fu Y</author>
                    <author ORCID="0009-0009-2536-8219" order="5">Hoezl R</author>
                    <author ORCID="0000-0003-2218-0076" order="6">Lv H</author>
                    <author ORCID="0000-0002-5433-6939" order="7">Abozeid HH</author>
                    <author order="8">Teo QW</author>
                    <author order="9">Pholcharee T</author>
                    <author ORCID="0000-0002-9267-5501" order="10">McGrath JJC</author>
                    <author ORCID="0000-0002-1826-4333" order="11">Changrob S</author>
                    <author order="12">Nelson SA</author>
                    <author order="13">Yasuhara A</author>
                    <author order="14">Huang M</author>
                    <author order="15">Zheng NY</author>
                    <author order="16">Chervin JC</author>
                    <author order="17">Li L</author>
                    <author order="18">Fernandez-Quintero ML</author>
                    <author order="19">Loeffler JR</author>
                    <author order="20">Rodriguez AJ</author>
                    <author order="21">Huang J</author>
                    <author ORCID="0000-0001-8162-8358" order="22">Swanson OM</author>
                    <author order="23">Balmaseda A</author>
                    <author order="24">Kuan G</author>
                    <author order="25">Campredon L</author>
                    <author ORCID="0000-0002-3067-751X" order="26">Kaitlynn Allen E</author>
                    <author order="27">Neumann G</author>
                    <author ORCID="0000-0002-9078-6697" order="28">Wu NC</author>
                    <author ORCID="0000-0001-5061-8296" order="29">Kawaoka Y</author>
                    <author ORCID="0000-0003-4121-776X" order="30">Krammer F</author>
                    <author order="31">Mejias A</author>
                    <author ORCID="0000-0002-0565-5239" order="32">Ramilo O</author>
                    <author ORCID="0000-0001-7955-0256" order="33">Thomas PG</author>
                    <author ORCID="0000-0002-9352-7877" order="34">Gordon A</author>
                    <author ORCID="0000-0001-7153-3769" order="35">Ward AB</author>
                    <author ORCID="0000-0002-3402-2609" order="36">Han J</author>
                    <author ORCID="0000-0002-3537-1245" order="37">Wilson PC</author>
                    <title>B cell imprinting in children impairs antibodies to the haemagglutinin stalk.</title>
                    <journal_abbreviation>Nature</journal_abbreviation>
                    <country>UK</country>
                    <year>2026</year>
                    <external_references type="PUBMED">41813896</external_references>
                    <external_references type="DOI">doi:10.1038/s41586-026-10248-6</external_references>
                    <external_references type="ISSN">1476-4687</external_references>
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                <details>Cryo-EM structure of NI06063_d30_103 Fab in complex with influenza virus hemagglutinin from A/Hong Kong/485197/2014 (H3N2)</details>
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    <sample>
        <name>Cryo-EM structure of NI06063_d30_103 Fab in complex with influenza virus hemagglutinin from A/Hong Kong/485197/2014 (H3N2)</name>
        <supramolecule_list>
            <complex_supramolecule supramolecule_id="1">
                <name>Cryo-EM structure of NI06063_d30_103 Fab in complex with influenza virus hemagglutinin from A/Hong Kong/485197/2014 (H3N2)</name>
                <parent>0</parent>
                <macromolecule_list>
                    <macromolecule>
                        <macromolecule_id>1</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>2</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>3</macromolecule_id>
                    </macromolecule>
                    <macromolecule>
                        <macromolecule_id>4</macromolecule_id>
                    </macromolecule>
                </macromolecule_list>
                <natural_source database="NCBI">
                    <organism ncbi="1679038">Influenza A virus (A/Hong Kong/485197/2014(H3N2))</organism>
                </natural_source>
            </complex_supramolecule>
        </supramolecule_list>
        <macromolecule_list>
            <protein_or_peptide macromolecule_id="1">
                <name>NI06063_d30_103 Fab heavy chain</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
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                </molecular_weight>
                <number_of_copies>3</number_of_copies>
                <recombinant_expression database="NCBI">
                    <recombinant_organism ncbi="9606">Homo sapiens</recombinant_organism>
                </recombinant_expression>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>QVHLVESGGGVVQPGRSLRLSCAASGFTFSNYGMHWVRQAPGKGLEWVAFISYDGSNEYYADSVKGRFTISRDYSKYTLY
LQMNSLRAEDTAVYYCAKDGQWLVRGAFDFWGQGTMVTVSS</string>
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                    <recombinant_organism ncbi="9606">Homo sapiens</recombinant_organism>
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QTEDEADYYCCSYAGGRGVFGGGTKLTVL</string>
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DIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCKSECITPNGSIPNDKPFQNVNRITYGA
CPRYVKHSTLKLATGMRNVPEKQTR</string>
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                    <recombinant_organism ncbi="9606">Homo sapiens</recombinant_organism>
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EKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTKKQLRENAEDMGNGCFKIYHKCDNACIGSIRNGTYDHN
VYRDEALNNRFQIKGVGYIPEAPRDGQAYVRKDGEWVLLSTFLGSENLYFQGSAWSHPQFEKGGGSGGGSHHHHHH</string>
                    <external_references type="UNIPROTKB">A0A0K0YAS1</external_references>
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            </protein_or_peptide>
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                <formula>NAG</formula>
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        </half_map_list>
    </interpretation>
</emd>
