2026-01-07 REL RCSB INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY RCSB RCSB 2025-04-27 2026-01-07 2026-01-07 2026-01-07 National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) HD107581 United States Cancer Prevention and Research Institute of Texas (CPRIT) RR230042 United States Structure of the MOR/Gi/Mitragynine Pseudoindoxil Complex, GTP-bound G-ACT-3 Robertson MJ Skiniotis G GPCR, Complex, Agonist, MEMBRANE PROTEIN Robertson MJ Modak A Papasergi-Scott MM Hu M Peroto MC Varga BR Majumdar S Kalathur R Blanchard SC Skiniotis G Non-equilibrium snapshots of ligand efficacy at the mu-opioid receptor. Nature UK 2025 41430437 doi:10.1038/s41586-025-10056-4 1476-4687 0006 NATUAS 9odl FULLOVERLAP EMDB EMD-70366 associated EM volume
Structure of the MOR/Gi/Mitragynine Pseudoindoxil Complex, GTP-bound G-ACT-3
 Mu Opioid Receptor Gi1 heterotrimer complex Mu Opioid Receptor Gi1 heterotrimer complex 0 1 2 3 4 Homo sapiens Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Homo sapiens 0.037671102 1 Spodoptera frugiperda LEVO PGSSGSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQD GKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFP NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVS CLGVTDDGMAVATGSWDSFLKIWN P62873 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Homo sapiens 0.007861143 1 Spodoptera frugiperda LEVO MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL P59768 Guanine nucleotide-binding protein G(i) subunit alpha-1 Homo sapiens 0.040415031000000004 1 Spodoptera frugiperda LEVO MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQS IIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLD RIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIY THFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF P63096 Mu-type opioid receptor Mus musculus 0.047910758 1 Spodoptera frugiperda LEVO MKTIIALSYIFCLVFADYKDDDDAMGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQT GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILC KIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLT FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTV DRTNHQLENLEAETAPLPDIHHHHHH P42866 MAGNESIUM ION 2.4305e-05 1 MG GUANOSINE-5'-TRIPHOSPHATE 0.0005231799999999999 1 GTP Mitragynine pseudoindoxyl 0.00041449499999999997 1 EIG singleParticle particle 7.5 ETHANE TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 0.6 1.8 FEI FALCON IV (4k x 4k) 50.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 3.6 FSC 0.143 CUT-OFF cryoSPARC 57982 ANGULAR RECONSTITUTION ANGULAR RECONSTITUTION emd_70366.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 380 380 380 0 0 0 380 380 380 364.8 364.8 364.8 90.0 90.0 90.0 X Y Z -1.3323487 2.4229531 -0.00035885285 0.03536902 0.96 0.96 0.96 0.43 AUTHOR emd_70366_additional_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 380 380 380 0 0 0 380 380 380 364.8 364.8 364.8 90.0 90.0 90.0 X Y Z -1.3626424 2.1687891 -0.00035719067 0.037435923 0.96 0.96 0.96 AUTHOR G protein local refinement emd_70366_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 380 380 380 0 0 0 380 380 380 364.8 364.8 364.8 90.0 90.0 90.0 X Y Z -0.4891566 1.196233 0.0003555899 0.04244068 0.96 0.96 0.96 AUTHOR emd_70366_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 380 380 380 0 0 0 380 380 380 364.8 364.8 364.8 90.0 90.0 90.0 X Y Z -0.551471 1.349257 0.00034722945 0.042456288 0.96 0.96 0.96 AUTHOR