2025-12-24 REL RCSB INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY RCSB RCSB 2025-04-30 2025-12-24 2025-12-24 2025-12-24 Not funded Globular domain of monkeypox virus OPG153 (A28) bound to antibody 02M12 Rundlet EJ Zhou L McLellan JS Monkeypox virus, neutralizing antibody, orthopoxvirus, VIRAL PROTEIN Paciello I Rundlet EJ Zhou L Realini G Perrone F Pierleoni G Troisi M Postal J Guivel-Benhassine F Porrot F Mullins CM Moschese D Cossu MV Sabaini F Accordini S Gianesini N Passarelli Mantovani R Panza F Fabbiani M Tumbarello M Antinori S Castilletti C Montagnani F Schwartz O Rappuoli R McLellan JS Andreano E Antigen-agnostic identification of poxvirus broadly neutralizing antibodies targeting OPG153. Sci Transl Med US 17 eaeb3840 eaeb3840 2025 41370398 doi:10.1126/scitranslmed.aeb3840 1946-6242 9og1 FULLOVERLAP EMDB EMD-70449 associated EM volume
Globular domain of monkeypox virus OPG13 (A28) bound to antibody 02M12
 Monkeypox virus OPG153 (A28) globular domain in complex with antibody 02M12 Monkeypox virus OPG153 (A28) globular domain in complex with antibody 02M12 0 1 2 3 Homo sapiens A28L Monkeypox virus 0.047960152 1 Homo sapiens LEVO MANIINLWNGIVPTVQDVNVASITAFKSMIDETWDKKIEANTCISRKHRNIIHEVIRDFMKAYPKMDENRKSPLGAPMQW LTQYYILKNEYHKTMLAYDDGSLNTKFKTLNIYMITNVGQYILYIVFCIISGKNHDGTPYIYDSEITSNDKNLINDRIKY ACKQILHGQLTMALRIRNKFMFIGSPMYLWFNVNGSHVYHEIYDRNVGFHNKEIGRLLYAFMYYLSISGRFLNDLALLKF TYLGESWTFSLSVPEYILYGLGYSVFDTIEKFSNDAILVYIRTNNRNGYDYAEFNKKGIVKVTEDKPDNDKRIHAIRLIN YSSDVQHIHFGFRNTLIIDNECTSIQSSAENATDTGHHQDSKINIEGSLEVLFQGPGHHHHHHHHSAWSHPQFEKGGASG GGGSGGSAWSNPQFEK Q8V4V0 Monoclonal antibody 02M12 heavy chain Homo sapiens 0.014123834999999998 1 Homo sapiens LEVO (PCA)VQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPNTGGTNYAQKFQGRVTMTRDTSI NTAYMDLSRLRSDDTAVYYCARGWRYSYLDCFDPWGQGTLVIVSSASTKGP Monoclonal antibody 02M12 light chain Homo sapiens 0.011953370999999999 1 Homo sapiens LEVO AIQMTQSPSSVSASVGDRVTITCRASQGISIWLAWYQQKPGKAPKLLINAASSLQSGVPSRFSGSGSGTDFTLTISSLQP EDFATYYCQQANSFPYTFGQGTKLEIKRTVAA singleParticle particle 0.22 8.0 ETHANE
1:1 molar ratio of OPG153 (1-366) + nonoclonal antibody 02M12 Fab
 TFS GLACIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 200 1.5 2.5 FEI FALCON IV (4k x 4k) 49.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION
Alphafold 3
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