2026-02-18 REL RCSB INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY RCSB RCSB 2025-05-06 2026-01-14 2026-01-14 2026-02-18 National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) 3P01AI158571-01A1S1 United States HCoV-229E S2P bound by one DH1533 Fab, focused map Wrapp D coronavirus spike, antibody, HCoV-229E, alphacoronavirus, VIRAL PROTEIN Liccione MF Scobey T Froggatt HM Pajon C Yount BL Yin Q Spence TN Walter EB Saunders KO Edwards RJ Baric RS Haynes BF Cain DW Sheahan TP Wrapp D A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain. Commun Biol UK 9 168 168 2025 41476125 doi:10.1038/s42003-025-09446-1 2399-3642 EMD-70507 consensus EM volume
HCoV-229E S2P bound by one DH1533 Fab, consensus map
 EMD-70442 other EM volume
HCoV-229E S2P bound by one DH1533 Fab, composite map
 EMDB EMD-70508 associated EM volume
HCoV-229E S2P bound by one DH1533 Fab, focused map
 EMDB EMD-70507 consensus EM volume
HCoV-229E S2P bound by one DH1533 Fab, consensus map
 EMDB EMD-70442 other EM volume
HCoV-229E S2P bound by one DH1533 Fab, composite map
 HCoV-229E spike protein bound by one copy of the antigen binding fragment from human mAb DH1533 HCoV-229E spike protein bound by one copy of the antigen binding fragment from human mAb DH1533 0 1 2 3 Human coronavirus 229E BN1/GER/2015 0.672 Surface glycoprotein Human coronavirus 229E BN1/GER/2015 Homo sapiens LEVO MFVLLVAYALLHIAGCQTTNGTNTSHSVCNGCVGHSENVFAVESGGYIPSNFAFNNWFLLTNTSSVVDGVVRSFQPLLLN CLWSVSGSQFTTGFVYFNGTGRGACKGFYSNASSDVIRYNINFEENLRRGTILFKTSYGAVVFYCTNNTLVSGDAHIPSG TVLGNFYCFVNTTIGNETTSAFVGALPKTVREFVISRTGHFYINGYRYFSLGDVEAVNFNVTNAATTVCTVALASYADVL VNVSQTAIANIIYCNSVINRLRCDQLSFDVPDGFYSTSPIQPVELPVSIVSLPVYHKHTFIVLYVNFEHRRGPGKCYNCR PAVINITLANFNETKGPLCVDTSHFTTQFVDNVKLARWSASINTGNCPFSFGKVNNFVKFGSVCFSLKDIPGGCAMPIMA NLVNSKSHNIGSLYVSWSDGDVITGVPKPVEGVSSFMNVTLNKCTKYNIYDVSGVGVIRISNDTFLNGITYTSTSGNLLG FKDVTNGTIYSITPCNPPDQLVVYQQAVVGAMLSENFTSYGFSNVVEMPKFFYASNGTYNCTDAVLTYSSFGVCADGSII AVQPRNVSYDSVSAIVTANLSIPFNWTTSVQVEYLQITSTPIVVDCSTYVCNGNVRCVELLKQYTSACKTIEDALRNSAM LESADVSEMLTFDKKAFTLANVSSFGDYNLSSVIPSLPRSGSRVAGRSAIEDILFSKLVTSGLGTVDADYKKCTKGLSIA DLACAQYYNGIMVLPGVADAERMAMYTGSLIGGIALGGLTSAASIPFSLAIQSRLNYVALQTDVLQENQRILAASFNKAM TNIVDAFTGVNDAITQTSQALQTVATALNKIQDVVNQQGNSLNHLTSQLRQNFQAISSSIQAIYDRLDPPQADQQVDRLI TGRLAALNVFVSHTLTKYTEVRASRQLAQQKVNECVKSQSKRYGFCGNGTHIFSLVNAAPEGLVFLHTVLLPTQYKDVEA WSGLCVDGINGYVLRQPNLALYKEGNYYRITSRIMFEPRIPTIADFVQIENCNVTFVNISRSELQTIVPEYIDVNKTLQE LSYKLPNYTVPDLVGSGYIPEAPRDGQAYVRKDGEWVLLSTFLGRSLEVLFQGPGHHHHHHHHSAWSHPQFEKGGGSGGG GSGGSAWSHPQFEK DH1533 heavy chain Homo sapiens LEVO EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGSNTYYADSVKGRFTISRDNAKNTLY LQMNSLRAEDTAVYYCAKDTTPRPLYSSGWYGSFDYWGQGTPVSVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYF PEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKGLEVLFQ DH1533 light chain Homo sapiens Homo sapiens LEVO DIQMTQSPSSLSASVGDRVTITCQASQDITTYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTLTISSLQP EDIATYYCQQYDNLFLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC singleParticle particle 0.35 8.0 2.0 C4H11NO3 Tris 200.0 NaCl sodium chloride 0.02 NaN3 sodium azide Quantifoil R1.2/1.3 COPPER 200 GLOW DISCHARGE ETHANE 100 277 FEI VITROBOT MARK IV TFS KRIOS OTHER BRIGHT FIELD FIELD EMISSION GUN 300 0.8 2.0 FEI TITAN KRIOS AUTOGRID HOLDER NITROGEN GATAN K3 BIOQUANTUM (6k x 4k) 1 19477 49.8 1 6573334 cryoSPARC v4.6.2
Patch CTF Estimation
PHASE FLIPPING AND AMPLITUDE CORRECTION C1 3.38 FSC 0.143 CUT-OFF cryoSPARC v4.6.2 202873 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_70508.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 432 432 432 0 0 0 432 432 432 466.56003 466.56003 466.56003 90.0 90.0 90.0 X Y Z -0.0014114142 2.464881 0.00047837812 0.016904822 1.08 1.08 1.08 0.3 AUTHOR Focused map, sharpened with DeepEMhancer emd_70508_msk_1.map emd_70508_additional_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 432 432 432 0 0 0 432 432 432 466.56003 466.56003 466.56003 90.0 90.0 90.0 X Y Z -0.51877433 0.987949 -0.00085722463 0.010475655 1.08 1.08 1.08 AUTHOR Focused map, unsharpened emd_70508_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 432 432 432 0 0 0 432 432 432 466.56003 466.56003 466.56003 90.0 90.0 90.0 X Y Z -0.69274133 1.2183666 -0.00022536956 0.047422763 1.08 1.08 1.08 AUTHOR Focused half map A emd_70508_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 432 432 432 0 0 0 432 432 432 466.56003 466.56003 466.56003 90.0 90.0 90.0 X Y Z -0.65180117 1.2231482 -0.00022450992 0.04719572 1.08 1.08 1.08 AUTHOR Focused half map B