2025-12-10 REL RCSB INITIAL_RELEASE REPOSITORY RCSB RCSB 2025-05-09 2025-12-10 2025-12-10 2025-12-10 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM143282 United States Cryo-EM structure of human SV2A in complex with levetiracetam Pidathala S Dai Y Lee CH SLC transporter, SLC22 family, MEMBRANE PROTEIN, inhibitor Pidathala S Chen X Dai Y Nguyen LN Gorgulla C Niu Y Liu F Lee CH Structural pharmacology of SV2A reveals an allosteric modulation mechanism in the major facilitator superfamily. Nat Commun UK 16 10748 10748 2025 41315229 doi:10.1038/s41467-025-65781-1 2041-1723 9okg FULLOVERLAP EMDB EMD-70563 associated EM volume
Cryo-EM structure of human SV2A in complex with levetiracetam
 Human SV2A in complex with levetiracetam Human SV2A in complex with levetiracetam 0 1 Homo sapiens Synaptic vesicle glycoprotein 2A Homo sapiens 0.067822164 1 Homo sapiens LEVO AQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVG AFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCM FWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVH DTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMS FSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFED VTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALL MDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAV LGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide 0.000170209 1 UKX singleParticle particle 7.0 ETHANE TFS KRIOS OTHER BRIGHT FIELD FIELD EMISSION GUN 300 2.7 1.1 2.1 GATAN K3 (6k x 4k) 70.5 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 2.58 FSC 0.143 CUT-OFF cryoSPARC 890424 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_70563.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 440 440 440 0 0 0 440 440 440 285.56 285.56 285.56 90.0 90.0 90.0 X Y Z -1.0829141 1.6653942 0.000133106 0.021172898 0.649 0.649 0.649 0.203 AUTHOR emd_70563_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 440 440 440 0 0 0 440 440 440 285.56 285.56 285.56 90.0 90.0 90.0 X Y Z -0.24321581 0.49393046 0.0003529066 0.028310576 0.649 0.649 0.649 AUTHOR emd_70563_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 440 440 440 0 0 0 440 440 440 285.56 285.56 285.56 90.0 90.0 90.0 X Y Z -0.25214446 0.4954381 0.00035184252 0.028446782 0.649 0.649 0.649 AUTHOR