Cryo-EM structure of vaccine-elicited antibody T3_NB_G05 in complex with HIV Env trimer Q23-APEX-GT1.N187S

2026-02-25 REL RCSB INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY DATABASE_REFERENCES citation citation_author em_admin _citation.country _citation.journal_abbrev _citation.journal_id_CSD _citation.journal_id_ISSN _citation.journal_volume _citation.page_first _citation.page_last _citation.pdbx_database_id_DOI _citation.pdbx_database_id_PubMed _citation.title _citation.year _em_admin.last_update EXPERIMENTAL_SUMMARY citation citation_author em_admin _citation.country _citation.journal_abbrev _citation.journal_id_CSD _citation.journal_id_ISSN _citation.journal_volume _citation.page_first _citation.page_last _citation.pdbx_database_id_DOI _citation.pdbx_database_id_PubMed _citation.title _citation.year _em_admin.last_update RCSB RCSB 2025-05-15 2025-11-12 2025-11-12 2026-02-25 National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) United States Cryo-EM structure of vaccine-elicited antibody T3_NB_G05 in complex with HIV Env trimer Q23-APEX-GT1.N187S Roark RS Shapiro LS Kwong PD Kwong PD immune complex, neutralizing antibody, V2 apex, mouse model, VIRAL PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM complex Ghosh AR Habib R Mishra N Roark RS Akauliya M Albowaidey AA Allen JD Amereh K Avillion G Bottermann M Liang B Chaudhary N Callaghan S Dye J Li X Ellis-Pugh JR Roy Chowdhury R James NE Liu X Maiorino L Villavicencio PM Nedellec R Oberoi P Sowers KJ Park Y Prum T Rodriguez L Ssozi M Torres JL Walsh AA Warner JE Weldon SR Xu L Wiehe K Crispin M Ward AB Nair U Hahn BH Burton DR Shapiro L Kwong PD Irvine DJ Andrabi R Shaw GM Batista FD Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization. Sci Immunol US 11 eadz5064 eadz5064 2026 41686913 doi:10.1126/sciimmunol.adz5064 2470-9468 9oog FULLOVERLAP EMDB EMD-70663 associated EM volume

T3_NB_G05 Fab in complex with HIV Env trimer Q23-APEX-GT1.N187S T3_NB_G05 Fab in complex with HIV Env trimer Q23-APEX-GT1.N187S 0 1 2 3 4 Macaca mulatta T3_NB_G05 heavy chain Mus musculus 0.025198158 3 Homo sapiens LEVO EVHLVESGGGLATPGGSLRLSCAASGFTFSNYWMNWVRQTPGKGLEWIASINSAGGARDYADSVMGRFTISRDNSKNTLS LKMNSLRTEDTAVYYCAKVDEDDYGYFSIVPGDLKKYYFKYWGQGVQVTVSSASTTPPSVYPLAPGSAAQTNSMVTLGCL VKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCG T3_NB_G05 light chain Mus musculus 0.023470697 3 Homo sapiens LEVO DIQMTQSPSSLSASVGDRVTITCQASQGISSWLAWYQQKPGKAPKSLIYKASSLESGVPSRFSGSGSGTDFTLTISSLQP EDFATYYCQQYDSAPFSFGQGTEVEIKRTDAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC HIV Env gp120 Homo sapiens 0.056704605 3 Homo sapiens LEVO MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARAENLWVTVYYGVPVWRDAETTLFCASDAKAYETEKHNVWATHACV PTDPNPQEIHLDNVTEKFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLHCTNVTSVNTTGDREELKNCSFNMTT ELRDKRQKVYSLFYRLDIVPINESQGSEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDEGFNGTGLCKNV STVQCTHGIKPVVSTQLLLNGSLAEKNITIRSENITNNAKIIIVQLVQPVTIKCIRPNNYTRKSIRIGPGQAFYAMGDII GDIRQAHCNVSRSRWNKTLQEVAEKLRTYFGNKTIIFANSSGGDLEITTHSFNCGGEFFYCNTSGLFNSTWYVNSTWNDT DSTQESNDTITLPCRIKQIINMWQRAGQCMYAPPIPGVIKCESNITGLLLTRDGGKDNNVNETFRPGGGDMRDNWRSELY KYKVVEIEPLGVAPTRCKRRVVE HIV Env gp41 ectodomain Homo sapiens 0.017205666 3 Homo sapiens LEVO AVGIGAVRRGFLGAAGSTMGAASITLTVQARQLLSGIVQPQNNLLRAPEAQQHLLKLGVWGIKQLQARVLAVERYLRDQQ LLGIWGCSGKLICCTNVPWNSSWSNKSLDEIWNNMTWLQWDKEIGNYTQLIYRLIEESQNQQEKNEKELLALD 2-acetamido-2-deoxy-beta-D-glucopyranose 0.000221208 31 NAG singleParticle particle 7.5

PBS

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