2025-07-30 REL RCSB INITIAL_RELEASE REPOSITORY RCSB RCSB 2025-06-17 2025-07-30 2025-07-30 2025-07-30 Howard Hughes Medical Institute (HHMI) NA United States Human EAAT3 with compound 3e and digitonin.glyco-diosgenin bound at inward facing state Qiu B Boudker O hEAAAT3, allosteric inhibitor, TRANSPORT PROTEIN Koochaki P Qiu B Coker JA Earsley A Wang NS Romigh T Goins CM Stauffer SR Boudker O Chakraborty AA Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer. Biorxiv US 2025 40672197 doi:10.1101/2025.07.03.663021 2692-8205 9p4y FULLOVERLAP human excitatory amino acid transporter 3 human excitatory amino acid transporter 3 0 1 Homo sapiens 0.56 Excitatory amino acid transporter 3 Homo sapiens 0.057275167999999994 1 Homo sapiens LEVO GPMGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITG VAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQAC FQQYKTKREEVKPPSDPEMTMTEESFTAVMTTAISKTKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVD FFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAM GMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITIS ITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSE VNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF P43005 (4R)-8-bromo-2-(furan-2-yl)-N-(2-methylphenyl)imidazo[1,2-a]pyridin-3-amine 0.00036822699999999994 1 A1CG9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en 0.0005448049999999999 1 9Z9 CHOLESTEROL 0.000386654 2 CLR water 1.8015e-05 4 HOH singleParticle particle 5 7.4 Quantifoil R1.2/1.3 GOLD 300 CARBON HOLEY ETHANE 100 298 FEI VITROBOT MARK IV TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 100.0 2.7 1.0 2.0 105000.0 NITROGEN GATAN K3 (6k x 4k) 58.0 1 6652777 PHASE FLIPPING AND AMPLITUDE CORRECTION 4 C1 2.56 FSC 0.143 CUT-OFF cryoSPARC 659546 MAXIMUM LIKELIHOOD cryoSPARC MAXIMUM LIKELIHOOD cryoSPARC 10 cryoSPARC emd_71289.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 320 320 320 0 0 0 320 320 320 265.6 265.6 265.6 90.0 90.0 90.0 X Y Z -4.6916776 6.964826 0.011148974 0.12852581 0.83000004 0.83000004 0.83000004 1.1 AUTHOR This is the full map 6X3F PDB experimental model OTHER 35.810000000000002 emd_71289_msk_1.map emd_71289_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 320 320 320 0 0 0 320 320 320 265.6 265.6 265.6 90.0 90.0 90.0 X Y Z -0.746567 1.8903612 0.006152242 0.08927211 0.83000004 0.83000004 0.83000004 AUTHOR This is the second half map emd_71289_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 320 320 320 0 0 0 320 320 320 265.6 265.6 265.6 90.0 90.0 90.0 X Y Z -0.73410463 1.8761121 0.0061626663 0.08931661 0.83000004 0.83000004 0.83000004 AUTHOR This is the first half map