2026-01-28 REL RCSB INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY RCSB RCSB 2025-08-01 2025-12-10 2025-12-10 2026-01-28 Bill & Melinda Gates Foundation INV-002916 United States National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) UM1 AI144462 United States 10E8-GT10.2 immunogen in complex with Rhesus macaque Fab W3-02 and mouse Fab W6-03 Huang J Ward AB HIV, Germline targeting, MPER, broadly neutralizing antibody, vaccine design, VIRAL PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM complex Huang J Swanson OM Rantalainen K Fernandez-Quintero ML Loeffler JR Tingle R Georgeson E Phelps N Ozorowski G Schiffner T Schief WR Ward AB Cryo-EM structures of antibodies elicited by germline-targeting HIV MPER epitope scaffolds. Cell Rep US 45 116818 116818 2026 41528847 doi:10.1016/j.celrep.2025.116818 2211-1247 Schiffner T Phung I Ray R Irimia A Tian M Swanson O Lee JH Lee CD Marina-Zarate E Cho SY Huang J Ozorowski G Skog PD Serra AM Rantalainen K Allen JD Baboo S Rodriguez OL Himansu S Zhou J Hurtado J Flynn CT McKenney K Havenar-Daughton C Saha S Shields K Schultze S Smith ML Liang CH Toy L Pecetta S Lin YC Willis JR Sesterhenn F Kulp DW Hu X Cottrell CA Zhou X Ruiz J Wang X Nair U Kirsch KH Cheng HL Davis J Kalyuzhniy O Liguori A Diedrich JK Ngo JT Lewis V Phelps N Tingle RD Spencer S Georgeson E Adachi Y Kubitz M Eskandarzadeh S Elsliger MA Amara RR Landais E Briney B Burton DR Carnathan DG Silvestri G Watson CT Yates JR Paulson JC Crispin M Grigoryan G Ward AB Sok D Alt FW Wilson IA Batista FD Crotty S Schief WR Vaccination induces broadly neutralizing antibody precursors to HIV gp41. Nat Immunol UK 25 1073 1082 2024 38816615 doi:10.1038/s41590-024-01833-w 1529-2916 EMDB EMD-71885 associated EM volume 10E8-GT10.2 immunogen in complex with rhesus macaque Fab W3-02 10E8-GT10.2 immunogen in complex with rhesus macaque Fab W3-02 0 1 2 3 4 5 W6-03 mouse Fab heavy chain, W6-10 mouse light chain 1 4 5 Mus musculus 10E8-GT10.2 immunogen 1 1 synthetic construct W3-02 Rhesus macaque Fab heavy chain, W3-02 Rhesus macaque Fab light chain 1 4 5 Homo sapiens 10E8-GT10.2 immunogen synthetic construct Homo sapiens LEVO NVTQEDIIRALASPLIKDGMVDEDFAEYVIARENRSPTGLQAKGVGVAIPHTLGDYVRDNAISVGILDKPVNFSGWYQSPDPVPVRVVFMLAGRTWDDIVIVLKWIKDVILDEEFMKRLLNMSDEEIYRQIYTRISKAPNLSGINFSREYVRHLN W3-02 Rhesus macaque Fab heavy chain Macaca mulatta Homo sapiens LEVO EVQLVESGGGLVQPGGSLKLSCAASGFTFSDHYMDWVRQAPGKGLEWVSSVSSGSGSATLYPDSVKGRFTISRDNAKNTVYLQMNSLRAEDTAVYYCARRGLYYDFWSGYSDFYYGLDSWGQGVVVTVSS W3-02 Rhesus macaque Fab light chain Macaca mulatta Homo sapiens LEVO DIVMTQTPLSLPITPGEPASISCRSSQSLLQSNGNTYLHWYLQKPGQSPQLLIYGGSNRASGVPDRFSGSGSGTDFTLKISKVEAEDVGVYYCVQAIAFPFTFGPGTKLDIK W6-03 mouse Fab heavy chain Mus musculus Homo sapiens LEVO DVQLQESGPGLVKPSQSLSLTCSVTGYSITSGYYWNWIRQFPGNKLEWMGYISYDGSNNYNPSLKNRISITRDTSQNQFFLKLNSVTTEDTASYYCAREGPYYDFWSGYYAYYMDVWGKGTTVTVSS W6-03 mouse Fab light chain Mus musculus Homo sapiens LEVO DIVMSQSPSSLAVSVGEKVTMSCKSSQSLLYSSNQKNYLAWYQQKPGQSPKLLIYWASTRKSGVPDRFTGSGSGTDFTLTISSVKAEDLAVYYCQQYFGYPLTFGAGTKLELK singleParticle particle 2.5 7.4 50.0 Tris 150.0 sodium chloride 0.005 Lauryl Maltose Neopentyl Glycol UltrAuFoil R1.2/1.3 GOLD 300 GOLD HOLEY GLOW DISCHARGE ETHANE 100 277 FEI VITROBOT MARK IV TFS GLACIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 200 0.7000000000000001 1.5 FEI FALCON IV (4k x 4k) 53.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION
Cryosparc Ab-initio
 4.2 FSC 0.143 CUT-OFF cryoSPARC 4 63258 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_71885.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 416 416 416 0 0 0 416 416 416 301.6 301.6 301.6 90.0 90.0 90.0 X Y Z -0.34902406 0.50812906 0.00012132897 0.007710537 0.725 0.725 0.725 0.08 AUTHOR emd_71885_msk_1.map emd_71885_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 416 416 416 0 0 0 416 416 416 301.6 301.6 301.6 90.0 90.0 90.0 X Y Z -0.2514011 0.36958778 0.00011726317 0.028025728 0.725 0.725 0.725 AUTHOR emd_71885_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 416 416 416 0 0 0 416 416 416 301.6 301.6 301.6 90.0 90.0 90.0 X Y Z -0.2699075 0.36546633 0.00011867554 0.028060595 0.725 0.725 0.725 AUTHOR