2026-02-25 REL RCSB INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY RCSB RCSB 2025-08-27 2026-01-28 2026-01-28 2026-02-25 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) United States Sinha KK Halic M Transcription factor, Oct4, Nucleosome, Protein-DNA complex, Chromatin binding, Gene Regulation, Pioneer Factor, DNA BINDING PROTEIN Sinha KK Halic M Sci Rep UK 16 5704 5704 2026 41554871 doi:10.1038/s41598-026-35959-8 2045-2322 Sinha KK Bilokapic S Du Y Malik D Halic M Nature UK 619 378 384 2023 37225990 doi:10.1002/jcc.20084 1476-4687 0006 NATUAS EMDB EMD-72371 associated EM volume Human Oct4 bound to a Nucleosome with human histones and human LIN28 DNA sequence Human Oct4 bound to a Nucleosome with human histones and human LIN28 DNA sequence 0 1 2 3 4 5 6 Homo sapiens OCT4 Homo sapiens Escherichia coli LEVO GSSHHHHHHSSGLVPRGSHMASMTGGQQMGRDPNSMAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGP GIGPGVGPGSEVWGIPPCPPPYEFCGGMAYCGPQVGVGLVPQGGLETSQPEGEAGVGVESNSDGASPEPCTVTPGAVKLE KEKLEQNPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQ KWVEEADNNENLQEICKAETLVQARKRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKG KRSSSDYAQREDFEAAGSPFSGGPVSFPLAPGPHFGTPGYGSPHFTALYSSVPFPEGEAFPPVSVTTLGSPMHSN Histone H2A Homo sapiens Escherichia coli LEVO S G R G K Q G G K A R A K A K T R S S R A G L Q F P V G R V H R L L R K G N Y A E R V G A G A P V Y L A A V L E Y L T A E I L E L A G N A A R D N K K T R I I P R H L Q L A I R N D E E L N K L L G K V T I A Q G G V L P N I Q A VL L P K K T E S H H K A K G K Histone H2B Homo sapiens Escherichia coli LEVO P E P S K S A P A P K K G S K K A I T K A Q K K D G K K R K R S R K E S Y S I Y V Y K V L K Q V H P D T G I S S K A M G I M N S F V N D I F E R I A G E A S R L A H Y N K R S T I T S R E I Q T A V R L L L P G E L A K H A V S E GT K A V T K Y T S S K Histone H3 Homo sapiens Escherichia coli LEVO A R T K Q T A R K S T G G K A P R K Q L A T K A A R K S A P A T G G V K K P H R Y R P G T V A L R E I R R Y Q K S T E L L I R K L P F Q R L V R E I A Q D F K T D L R F Q SS A V M A L Q E A C E A Y L V G L F E D T N L C A I H A KR V T I M P K D I Q L A R R I R G E R A Histone H4 Homo sapiens Escherichia coli LEVO MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG LIN28B DNA Homo sapiens GCAT AAG TTA AGT GGT ATT AAC ATA TCC TCA GTG GTG AGT ATT AAC ATG GAA CTT ACT CCA ACA ATA CAG ATG CTG AAT AAA TGT AGT CTA AGT GAA GAA AGA AGG AAA GGT GGG AGC TGC CAT CAC TCA GAA TTG TCC AGC AGG GAT TGT GCA AGC TTG TGA ATA AAG ACA CAT ACT TCA T DNA singleParticle particle 7.5 50.0 HEPES 1.0 DTT Quantifoil R2/1 COPPER 300 CARBON HOLEY NITROGEN 95 10 FEI VITROBOT MARK IV FEI TALOS ARCTICA FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 200 0.7000000000000001 3.0 GATAN K3 (6k x 4k) 60.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 6.0 FSC 0.143 CUT-OFF cryoSPARC 15080 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_72371_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 256 256 256 0 0 0 256 256 256 267.264 267.264 267.264 90.0 90.0 90.0 X Y Z -1.6594421 1.6907871 0.002769203 0.21416508 1.044 1.044 1.044 AUTHOR ::::EMDATABANK.org::::EMD-72371:::: Oct4 bound to LIN28B nucleosome - half map A emd_72371_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 256 256 256 0 0 0 256 256 256 267.264 267.264 267.264 90.0 90.0 90.0 X Y Z -1.6008569 1.712853 0.0026949919 0.21337454 1.044 1.044 1.044 AUTHOR ::::EMDATABANK.org::::EMD-72371:::: Oct4 bound to LIN28B nucleosome - half map B