2026-03-18 REL RCSB INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY RCSB RCSB 2025-10-06 2026-03-18 2026-03-18 2026-03-18 Other private cryoEM structure of Aspergillus fumigatus acetolactate synthase (ALS) in complex with a novel inhibitor Hu Y antifungal target, herbicide target, anti fugal infection, natural product, PLANT PROTEIN Perlatti B Vellanki S Zhang Y Chiang YM Hu Y Yuan M Dunbar K Fine A Grau MF Li S O'Donnell T Shenoy R Li H Shi H Xu X Chen Z Arvedson T Tang Y Cramer RA Cee V Harvey CJB An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining. Acs Cent.Sci. US 12 197 207 2026 41768770 doi:10.1021/acscentsci.5c02019 2374-7951 9yk0 FULLOVERLAP EMDB EMD-73041 associated EM volume
cryoEM structure of Aspergillus fumigatus acetolactate synthase (ALS) in complex with a novel inhibitor
 Aspergillus fumigatus Acetolactate synthase Aspergillus fumigatus Acetolactate synthase 0 1 Aspergillus fumigatus 0.133 Acetolactate synthase Aspergillus fumigatus 0.070307812 2 Escherichia coli LEVO SPAFNQEPHRNEVSPLQNRHLPELDDSTSLITVMSRFVGLSGGQIFHEMMLRLGVKHIFGYPGGAILPVFDAIYNSKHFD FVLPRHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVITPMQDALSDGTPMVVFCGQVPTSSIGTDSFQEADVVGISRA CTKWNVMVKSVAELPRRIQEAFEIATSGRPGPVLVDLPKDITAGILRKPIPMNSTIPSLPSAATMAARELSMKQLESSID RVARLVNIAQKPVLYVGQGLLARPDGPKVLKELADKACIPVTTTLQGLGGFDELDPKALHMLGMHGSAYANMAMQEADLI IAVGARFDDRVTGNLSKFAPQAKLAASEKRGGIVHFEIMPKNINKVVQANEAVEGDCAENIRLLLPHVKPVSERPEWFAQ INDWKARFPFSLYEKQSPEGPIKPQALIEKLSDLTAPIKDRTIITTGVGQHQMWAAQHFRWRHPRTMITSGGLGTMGYGL PAAIGAKVARPDCLVIDIDGDASFNMTLTELTTAAQFNIGVKVLLLNNEEQGMVTQWQNLFYEDRYSHTHQKNPDFVPMA RSMGVAAERCTKPSEVEEKLKWLIESDGPALLEVFTDRKVPVLPMVPAGSALHEFLVYDEAKEKERKALLRSRTAPEYLH K B0XXW9 2.2.1.6 MAGNESIUM ION 2.4305e-05 2 MG THIAMINE DIPHOSPHATE 0.000425314 2 TPP FLAVIN-ADENINE DINUCLEOTIDE 0.0007855499999999999 2 FAD (1R,2R,4aR,8R,8aR)-8-[(3S,5R)-5-(3-hydroxypropyl)-2,4-dioxopyrrolidin-3-yl]-3,8-dimethyl-2-propyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbaldehyde 0.000389528 2 A1CXH singleParticle particle 8.0 ETHANE TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 1.0 2.4 FEI FALCON IV (4k x 4k) 65.0 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 5IMS 2.36 FSC 0.143 CUT-OFF cryoSPARC 125472 PROJECTION MATCHING MAXIMUM LIKELIHOOD emd_73041.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 384 384 384 0 0 0 384 384 384 285.31198 285.31198 285.31198 90.0 90.0 90.0 X Y Z -0.32800797 0.6371386 -0.00008038378 0.012317208 0.743 0.743 0.743 0.15 AUTHOR emd_73041_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 384 384 384 0 0 0 384 384 384 285.31198 285.31198 285.31198 90.0 90.0 90.0 X Y Z -0.63305795 0.7810128 0.000106582505 0.078424774 0.743 0.743 0.743 AUTHOR emd_73041_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 384 384 384 0 0 0 384 384 384 285.31198 285.31198 285.31198 90.0 90.0 90.0 X Y Z -0.719866 0.73059493 0.000107547545 0.078515165 0.743 0.743 0.743 AUTHOR