2026-04-08 REL RCSB INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY INITIAL_RELEASE REPOSITORY DATABASE_REFERENCES citation citation_author em_admin _citation.country _citation.journal_abbrev _citation.journal_id_ASTM _citation.journal_id_CSD _citation.journal_id_ISSN _citation.pdbx_database_id_DOI _citation.pdbx_database_id_PubMed _citation.title _citation.year _em_admin.last_update EXPERIMENTAL_SUMMARY citation citation_author em_admin _citation.country _citation.journal_abbrev _citation.journal_id_ASTM _citation.journal_id_CSD _citation.journal_id_ISSN _citation.pdbx_database_id_DOI _citation.pdbx_database_id_PubMed _citation.title _citation.year _em_admin.last_update RCSB RCSB 2026-01-15 2026-03-25 2026-03-25 2026-04-08 National Institutes of Health/National Institute of Mental Health (NIH/NIMH) MH085926 United States SK5A-Matured apo state in complex with GluN1-GluN2B, full refinement Kleeman SO Furukawa HF NMDAR, antibody, SIGNALING PROTEIN, SIGNALING PROTEIN-Immune System complex Kleeman SO Michalski K Zhao X Steigerwald R Ferrer M Levett L Ertel E Schultz A Simorowski N Moody P Wee TL Valente C Fox S Makuch M Thomsen S Harrison R Regan C Preall J Gao Q Thomas D Habel J Rubino R Irani S Furukawa H Janowitz T Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity. Nature UK 2026 41882353 doi:10.1038/s41586-026-10278-0 1476-4687 0006 NATUAS 10ex FULLOVERLAP EMDB EMD-75121 associated EM volume
SK5A-Matured apo state in complex with GluN1-GluN2B, full refinement
 SK3D IgG in complex with GluN1-GluN2B NMDAR protein SK3D IgG in complex with GluN1-GluN2B NMDAR protein 0 1 2 3 4 Homo sapiens Isoform 4 of Glutamate receptor ionotropic, NMDA 1 Homo sapiens 0.091827914 2 Spodoptera frugiperda LEVO KIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTP TPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLL EERESKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPD GIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDG DRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEF TVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGE LLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMNPFQSTLWLLVGLSVHVVAVMLYLLDRFS PFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERI TGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKC DLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMIVAGGI VAGIFLIFIEIAYKSRA Q5R1P0 Glutamate receptor ionotropic, NMDA 2B Homo sapiens 0.08867323399999999 2 Spodoptera frugiperda LEVO FHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKD ESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQN QLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIA IITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGK WKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCEKRIVTENKTDEEPGYIKKCCK GFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMV SRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSV PVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN YAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDL AILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFISEHLFYWQ Q13224 Light chain Mus musculus 0.011642847999999999 2 Homo sapiens LEVO DIQMTQSPSSLSASLGERVSLTCRASQDIGSTLIWLQQEPDGTIKRLIYATSSLDSGVPKRFSGSRSGSDYSLTISSLES EDFVDYYCLQYASSPYTFGGGTKLEIK Heavy chain Mus musculus 0.012669979999999999 2 Homo sapiens LEVO EVQLQQSGAELVKPGASVKLSCTASGFNIKDTYIHWVKQRPEQGLEWIGRIDPANGNTKYDPKFQGKATVTADTSSNAAY LHLSSLTSEDTAVYYCARSYDSFAYWGQGTLVTVSA singleParticle particle 5 7.4 ETHANE FEI VITROBOT MARK IV TFS KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 0.8 2.2 GATAN K3 BIOCONTINUUM (6k x 4k) 71.7 1 PHASE FLIPPING AND AMPLITUDE CORRECTION 7SAA 4.08 FSC 0.143 CUT-OFF cryoSPARC 114482 RANDOM ASSIGNMENT OTHER
cryoSPARC refinement
 emd_75121.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 400 400 400 0 0 0 400 400 400 400.0 400.0 400.0 90.0 90.0 90.0 X Y Z -0.3151775 0.45273024 -0.00028712527 0.009144462 1.0 1.0 1.0 0.07 AUTHOR SK5A-Matured apo state in complex with GluN1-GluN2B, full refinement emd_75121_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 400 400 400 0 0 0 400 400 400 342.4 342.4 342.4 90.0 90.0 90.0 X Y Z -0.30716082 0.4335274 0.0003011666 0.03160286 0.856 0.856 0.856 AUTHOR Half Map A emd_75121_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 400 400 400 0 0 0 400 400 400 342.4 342.4 342.4 90.0 90.0 90.0 X Y Z -0.32103664 0.4093768 0.00030218056 0.031362675 0.856 0.856 0.856 AUTHOR Half Map B